Estudio clínico y epidemiológico de la criptococosis en Colombia: Resultados de nueve años de la encuesta nacional, 1997-2005

Jairo Lizarazo, Melva Linares, Catalina de Bedout, Angela Restrepo, Clara Inés Agudelo, Elizabeth Castañeda, Sandra Huérfano, Gerzaín Rodríguez, Nidia Torres, Claudia Linares, Carlos Álvarez, Erick Sánchez, Clímaco Ernesto Ojeda, Sandra Núñez, Mónica Gutiérrez, Henry Mendoza, José Fernando Muñoz, Stella Mariño, Pilar Rivas, Jorge CortésMauricio Zuñiga, Felipe Arboleda, Pablo Lorenzana, Elsy Ospina, María Isabel Medina, Mario Mendoza, Myrtha Arango, Ángela María Tobón, Sergio Jaramillo, Alejandro Vélez, Carlos Andrés Agudelo, Ana Lucía Correa, Santiago Estrada, Marcela Gaviria, Jaime Robledo, Jaime Sanpedro, Roberto Panesso, Liliana Franco, Antonio de Castro, Martha Jácome, Martha Rincón, María Claudia Rodríguez, Yenny Peña, Jaime Galindo, Nancy Villamarín, Mónica Recalde, Claudia Rocío Castañeda, Mercedes Cano Henao, Martha Cecilia Kogson, Hernando Estrada, Máximo Mercado

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

44 Citas (Scopus)

Resumen

Inroduction. A national survey on cryptococcosis has been conducted in Colombia since 1997. The survey data recorded over a 9-year period, 1997 to 2005, was summarized. Materials and methods. The format provided by the European Confederation of Medical Mycology was adapted with the correspondent permission. Results. Over the 9 year period, 931 surveys were received from 76 centers. The associated disease syndromes were as follows: 891 (95.7%) were neurocryptococosis cases, 27 (2.9%) pulmonary disease, 5 (0.5%) cutaneous lesions, 2 (0.2%) ganglionar forms, 2 (0.2%) oropharyngeal lesions and one case (0.1%) each from peritonitis, liver lesion, cellulitis and urinary tract infection. Demographic data indicated 82.7% of the subjects were males, and 59.4% were between 20-39 years old; 25 children less than 16 years old were reported. The prevalent riA factor was HIV infection (78.1%). The mean annual incidence rate of cryptococcosis in the general population was 2.4 × 106 inhabitants, but in AIDS patients the rate rose to one in 3 × 103. The most frequent clinical features were headache (85.2%), nausea and vomiting (59.1%), fever (59.0%), mental changes (46.2%), meningeal signs (33.4%), cough (23.6%) and visual alterations or loss of vision (20.9%). Laboratory data showed that direct examination of cerebrospinal fluid (CSF) was positive in 92.8% cases and Cryptococcus was recovered in 90.3% of the cases. Cryptococcal antigen reactivity was 98.9% in CSF and 93.7% in serum samples. From 788 isolates submitted, 95.9% were C. neoformans var. grubii serotype A, 0.3% var. neoformans serotype D, 3.3% C. gattii serotype B and 0.5% C. gattii serotype C. The majority of patients were treated initially with amphotericin B. Conclusion. Cryptococcosis incidence has increased dramatically in Colombia with the AIDS pandemic and it can be considered as a sentinel marker for HIV infection.

Título traducido de la contribuciónResults of nine years of the clinical and epidemiological survey on cryptococcosis in Colombia, 1997-2005
Idioma originalEspañol
Páginas (desde-hasta)94-109
Número de páginas16
PublicaciónBiomedica
Volumen27
N.º1
DOI
EstadoPublicada - 2007
Publicado de forma externa

Palabras clave

  • AIDS
  • Colombia
  • Cryptococcosis
  • Cryptococcus neoformans
  • Morbidity
  • Mortality

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