TY - JOUR
T1 - Fabrication and characterization of electrospun membranes with highly lipoprotein repellent properties
AU - Rivera-Rivera, L. M.
AU - Moreno-Bárcenas, A.
AU - Hernández-Navarro, N.
AU - Ornelas-Soto, N. E.
AU - Hoyos-Palacio, L. M.
AU - Hernández-Rangel, A.
AU - Garcia-Garcia, A.
N1 - Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/8/1
Y1 - 2022/8/1
N2 - The present work presents an alternative for synthesizing low-density lipoprotein repellent membranes by the electrospinning technique. The membranes were fabricated with phosphorylcholine plus butyl methacrylate (PMB) and reinforced with nitrogen-doped graphene oxide functionalized with cysteamine (rGON-cis). The PMB concentration effects, the amount of the functionalizing agent, and the electrospinning parameters (polymer outflow and applied voltage) were studied. The maximum fiber length, average fiber diameter, diameter uniformity, and fiber quality were evaluated. The PMB membranes reinforced with rGON-cis showed an increase in the repulsion of low-density lipoproteins in function to oxidation degree. The repulsion of the membrane towards the low-density lipoproteins with medium oxidation was 26% ± 4. In contrast, the low-density lipoproteins with high oxidation increased the repulsion by 33% concerning the polymer without reinforcement.
AB - The present work presents an alternative for synthesizing low-density lipoprotein repellent membranes by the electrospinning technique. The membranes were fabricated with phosphorylcholine plus butyl methacrylate (PMB) and reinforced with nitrogen-doped graphene oxide functionalized with cysteamine (rGON-cis). The PMB concentration effects, the amount of the functionalizing agent, and the electrospinning parameters (polymer outflow and applied voltage) were studied. The maximum fiber length, average fiber diameter, diameter uniformity, and fiber quality were evaluated. The PMB membranes reinforced with rGON-cis showed an increase in the repulsion of low-density lipoproteins in function to oxidation degree. The repulsion of the membrane towards the low-density lipoproteins with medium oxidation was 26% ± 4. In contrast, the low-density lipoproteins with high oxidation increased the repulsion by 33% concerning the polymer without reinforcement.
KW - Doped graphene oxide
KW - Electrospun coating
KW - Functional material
KW - Lipophobic surface
KW - Low dimensional material
UR - http://www.scopus.com/inward/record.url?scp=85130510808&partnerID=8YFLogxK
U2 - 10.1016/j.matchemphys.2022.126281
DO - 10.1016/j.matchemphys.2022.126281
M3 - Artículo en revista científica indexada
AN - SCOPUS:85130510808
SN - 0254-0584
VL - 287
JO - Materials Chemistry and Physics
JF - Materials Chemistry and Physics
M1 - 126281
ER -