Fractional Diffusion Modulates Distribution of Action Potential Duration in Fibrotic Atrial Strands

Juan P. Ugarte, Catalina Tobon, Laura C. Palacio, Henry Andrade-Caicedo, Javier Saiz

    Producción científica: Capítulo del libro/informe/acta de congresoPonencia publicada en las memorias del evento con ISBNrevisión exhaustiva


    Background: Fibroblast proliferation, as a component of the fibrotic process, plays a role in structural remodeling, but also can alter the electrophysiology of the cardiomyocytes. Aim: To study the action potential duration dispersion (dAPD) in fibrotic atrial strands, where fibroblasts exerts both, structural and electrical influence on the propagation, using a fractional diffusion model. Methods: The Courtemanche model of human atrial cell is implemented under chronic atrial fibrillation (AF) remodeling conditions. The atrial strands are designed as 1D domains, having a fibrotic portion localized in the middle. Fibrosis is modeled taking into account an electrical component, implemented by coupling a number of fibroblasts to a single cardiomyocyte, and a structural component, implemented through a q-order fractional derivative. Results: The variations of q define two dAPD dispersion regimes. For q < 1.4, the fibrosis density and the number of fibroblast per cardiomyocyte do not alter the dAPD. For q ≥ 1.4, the dAPD depends on the fibrosis spatial characteristics. Conclusion: This study shows that the structural component of fibrosis, modeled using fractional diffusion, modulates the spatial dAPD in a domain including electrical coupling of cardiomyocytes and fibroblasts, under chronic AF conditions.

    Idioma originalInglés
    Título de la publicación alojadaComputing in Cardiology Conference, CinC 2018
    EditorialIEEE Computer Society
    ISBN (versión digital)9781728109589
    EstadoPublicada - sep. 2018
    Evento45th Computing in Cardiology Conference, CinC 2018 - Maastricht, Países Bajos
    Duración: 23 sep. 201826 sep. 2018

    Serie de la publicación

    NombreComputing in Cardiology
    ISSN (versión impresa)2325-8861
    ISSN (versión digital)2325-887X


    Conferencia45th Computing in Cardiology Conference, CinC 2018
    País/TerritorioPaíses Bajos

    Nota bibliográfica

    Publisher Copyright:
    © 2018 Creative Commons Attribution.


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