From immunosuppression to autoimmunity: PR3+ ANCA-associated vasculitis in a patient immunosuppressed for hepatic transplant. A case report

Oscar Vicente Vergara Serpa; Carlos Jaime Velásquez-Franco; Luis Fernando Pinto; Neil Smith Pertuz Charris; Andrés Felipe Echeverri García; Alejandro Cardona Palacio; Javier Darío Márquez Hernández

doi:10.1016/j.rcreu.2024.05.005

From immunosuppression to autoimmunity: PR3+ ANCA-associated vasculitis in a patient immunosuppressed for hepatic transplant. A case report

Título traducido de la contribución: De la inmunosupresión a la autoinmunidad: vasculitis ANCA-PR3+ en una paciente inmunosuprimida por trasplante hepático. Reporte de un caso

Oscar Vicente Vergara Serpa
, Carlos Jaime Velásquez-Franco
, Luis Fernando Pinto
, Neil Smith Pertuz Charris
, Andrés Felipe Echeverri García
, Alejandro Cardona Palacio
, Javier Darío Márquez Hernández

Grupo de Investigación en Medicina Interna y Cuidado Crítico

Producción científica: Contribución a una revista científica › Artículo en revista científica indexada › revisión exhaustiva

Resumen

Objective: To present the case of an immunosuppressed patient who developed an autoimmune disease. Patients and methods: 30-year-old woman, immunosuppressed due to a history of orthotopic liver transplant, who developed intestinal infection by cytomegalovirus and alveolar haemorrhage. Results: Patient presented a positive serological finding for PR3 ANCA, classified as granulomatosis with polyangiitis. Due to her history, induction, and maintenance with an anti-CD20 were considered, with no further relapse over 6-month follow-up. Conclusion: Immunosuppressed patients have risk factors for developing autoimmune diseases.

Título traducido de la contribución	De la inmunosupresión a la autoinmunidad: vasculitis ANCA-PR3+ en una paciente inmunosuprimida por trasplante hepático. Reporte de un caso
Idioma original	Inglés
Publicación	Revista Colombiana de Reumatologia
DOI	https://doi.org/10.1016/j.rcreu.2024.05.005
Estado	Publicada - 2024

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Publisher Copyright:
© 2024 Asociación Colombiana de Reumatología

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Vergara Serpa, O. V., Velásquez-Franco, C. J., Pinto, L. F., Pertuz Charris, N. S., Echeverri García, A. F., Cardona Palacio, A., & Márquez Hernández, J. D. (2024). From immunosuppression to autoimmunity: PR3+ ANCA-associated vasculitis in a patient immunosuppressed for hepatic transplant. A case report. Revista Colombiana de Reumatologia. https://doi.org/10.1016/j.rcreu.2024.05.005

@article{e5b3c35e003e469ca691bf884575e453,

title = "From immunosuppression to autoimmunity: PR3+ ANCA-associated vasculitis in a patient immunosuppressed for hepatic transplant. A case report",

abstract = "Objective: To present the case of an immunosuppressed patient who developed an autoimmune disease. Patients and methods: 30-year-old woman, immunosuppressed due to a history of orthotopic liver transplant, who developed intestinal infection by cytomegalovirus and alveolar haemorrhage. Results: Patient presented a positive serological finding for PR3 ANCA, classified as granulomatosis with polyangiitis. Due to her history, induction, and maintenance with an anti-CD20 were considered, with no further relapse over 6-month follow-up. Conclusion: Immunosuppressed patients have risk factors for developing autoimmune diseases.",

keywords = "ANCA-associated vasculitis, Blood-air barrier, Cytomegalovirus, Granulomatosis with polyangiitis, Liver transplantation",

author = "\{Vergara Serpa\}, \{Oscar Vicente\} and Vel{\'a}squez-Franco, \{Carlos Jaime\} and Pinto, \{Luis Fernando\} and \{Pertuz Charris\}, \{Neil Smith\} and \{Echeverri Garc{\'i}a\}, \{Andr{\'e}s Felipe\} and \{Cardona Palacio\}, Alejandro and \{M{\'a}rquez Hern{\'a}ndez\}, \{Javier Dar{\'i}o\}",

note = "Publisher Copyright: {\textcopyright} 2024 Asociaci{\'o}n Colombiana de Reumatolog{\'i}a",

year = "2024",

doi = "10.1016/j.rcreu.2024.05.005",

language = "Ingl{\'e}s",

journal = "Revista Colombiana de Reumatologia",

issn = "0121-8123",

publisher = "Asociacion Colombiana de Reumatologia",

}

From immunosuppression to autoimmunity: PR3+ ANCA-associated vasculitis in a patient immunosuppressed for hepatic transplant. A case report. / Vergara Serpa, Oscar Vicente; Velásquez-Franco, Carlos Jaime; Pinto, Luis Fernando et al.
En: Revista Colombiana de Reumatologia, 2024.

Producción científica: Contribución a una revista científica › Artículo en revista científica indexada › revisión exhaustiva

TY - JOUR

T1 - From immunosuppression to autoimmunity

T2 - PR3+ ANCA-associated vasculitis in a patient immunosuppressed for hepatic transplant. A case report

AU - Vergara Serpa, Oscar Vicente

AU - Velásquez-Franco, Carlos Jaime

AU - Pinto, Luis Fernando

AU - Pertuz Charris, Neil Smith

AU - Echeverri García, Andrés Felipe

AU - Cardona Palacio, Alejandro

AU - Márquez Hernández, Javier Darío

PY - 2024

Y1 - 2024

N2 - Objective: To present the case of an immunosuppressed patient who developed an autoimmune disease. Patients and methods: 30-year-old woman, immunosuppressed due to a history of orthotopic liver transplant, who developed intestinal infection by cytomegalovirus and alveolar haemorrhage. Results: Patient presented a positive serological finding for PR3 ANCA, classified as granulomatosis with polyangiitis. Due to her history, induction, and maintenance with an anti-CD20 were considered, with no further relapse over 6-month follow-up. Conclusion: Immunosuppressed patients have risk factors for developing autoimmune diseases.

AB - Objective: To present the case of an immunosuppressed patient who developed an autoimmune disease. Patients and methods: 30-year-old woman, immunosuppressed due to a history of orthotopic liver transplant, who developed intestinal infection by cytomegalovirus and alveolar haemorrhage. Results: Patient presented a positive serological finding for PR3 ANCA, classified as granulomatosis with polyangiitis. Due to her history, induction, and maintenance with an anti-CD20 were considered, with no further relapse over 6-month follow-up. Conclusion: Immunosuppressed patients have risk factors for developing autoimmune diseases.

KW - ANCA-associated vasculitis

KW - Blood-air barrier

KW - Cytomegalovirus

KW - Granulomatosis with polyangiitis

KW - Liver transplantation

UR - https://www.scopus.com/pages/publications/85200854907

U2 - 10.1016/j.rcreu.2024.05.005

DO - 10.1016/j.rcreu.2024.05.005

M3 - Artículo en revista científica indexada

AN - SCOPUS:85200854907

SN - 0121-8123

JO - Revista Colombiana de Reumatologia

JF - Revista Colombiana de Reumatologia

ER -

From immunosuppression to autoimmunity: PR3+ ANCA-associated vasculitis in a patient immunosuppressed for hepatic transplant. A case report

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