Functionalization of Electrospun Scaffolds with Gold or Silver Nanoparticles for Applications in Cardiovascular Tissue Engineering

W. Agudelo, Y. Montoya, A. Garcia-Garcia, J. Bustamante

Producción científica: Capítulo del libro/informe/acta de congresoPonencia publicada en las memorias del evento con ISBNrevisión exhaustiva

1 Cita (Scopus)

Resumen

The biocomposite materials development based on polymeric fibrillar structures functionalized with metal nanostructures are visualized as alternative strategies to facilitate tissue connection bridges in the engineering of cardiovascular tissues. Based on it, the purpose of the present investigation sought to functionalize silk fibroin electrospun membranes extracted from Colombian sericultural wastes with gold or silver nanoparticles synthesized by green chemical reduction method, estimating their biocompatible characteristics through interaction with an in vitro model of human fetal ventricular cardiomyocytes RL-14. The biocomposite material was characterized by UV-Visible spectroscopy, scanning electron and field emission microscopy. Besides, bright field microscopy was used to evaluate the adhesion and proliferation of cardiomyocytes RL-14. The results showed that the use of silk fibroin extracted from sericultural wastes favored the formation of $AuNPs-SF_{w}$ and $AgNPs-SF_{w}$ acting it as a reducing agent and surfactant forming a micellar structure around individual nanoparticles. Moreover, it was possible to obtain SFR/PEO membranes, which, being functionalized with nanoparticles, allowed the development of composite materials by layers. Finally, the use of three-dimensional protein structures functionalized with gold nanoparticles promoted cell attachment sites and favored the cytocompatible response.

Idioma originalInglés
Título de la publicación alojada2021 Global Medical Engineering Physics Exchanges/Pan American Health Care Exchanges, GMEPE/PAHCE 2021
EditorialIEEE Computer Society
ISBN (versión digital)9781728170534
DOI
EstadoPublicada - 15 mar. 2021
Evento2021 Global Medical Engineering Physics Exchanges/Pan American Health Care Exchanges, GMEPE/PAHCE 2021 - Virtual, Sevilla, Espana
Duración: 15 mar. 202120 mar. 2021

Serie de la publicación

NombrePan American Health Care Exchanges, PAHCE
Volumen2021-May
ISSN (versión impresa)2327-8161
ISSN (versión digital)2327-817X

Conferencia

Conferencia2021 Global Medical Engineering Physics Exchanges/Pan American Health Care Exchanges, GMEPE/PAHCE 2021
País/TerritorioEspana
CiudadVirtual, Sevilla
Período15/03/2120/03/21

Nota bibliográfica

Publisher Copyright:
© 2021 IEEE.

Huella

Profundice en los temas de investigación de 'Functionalization of Electrospun Scaffolds with Gold or Silver Nanoparticles for Applications in Cardiovascular Tissue Engineering'. En conjunto forman una huella única.

Citar esto