TY - JOUR
T1 - Genotoxicity through exposure to particulate matter (PM10) at two sites in the Valle de Aburrá, Colombia
AU - Estrada-Vélez, Verónica
AU - López-López, Lucelly
AU - Martínez-Sánchez, Lina María
AU - Agudelo-Vélez, Camilo Andrés
AU - Rodriguez-Gázquez, María de Los Ángeles
AU - Toro-Gómez, María Victoria
AU - Orozco-Jimenez, Luz Yaneth
AU - Zuluaga-Quintero, Mónica
AU - Lopera-Valle, Johan Sebastián
AU - Pamplona-Sierra, Ana Paulina
AU - Díaz-Zuluaga, Ana María
AU - Vargas-Grisales, Natalia
AU - Vargas-Gallego, Ana María
AU - Rojas-Londoño, Jennifer
AU - Hernández-Restrepo, Felipe
AU - Ocampo-Patiño, Andrea
AU - Rojas-Jimenez, Sara
AU - Ortiz-Trujillo, Isabel Cristina
N1 - Publisher Copyright:
© 2019 Verónica Estrada-Vélez, Lucelly López-López, Lina María Martínez-Sánchez, Camilo Andrés Agudelo-Vélez, María de los Ángeles Rodriguez-Gázquez, María Victoria Toro-Gómez, Luz Yaneth Orozco-Jimenez, Mónica Zuluaga-Quintero, Johan Sebastián Lopera-Valle, Ana Paulina Pamplona-Sierra, Ana María Díaz-Zuluaga, Natalia Vargas-Grisales, Ana María Vargas-Gallego, Jennifer Rojas-Londoño, Felipe Hernández-Restrepo andrea Ocampo-Patiño, Sara Rojas-Jimenez and Isabel Cristina Ortiz-Trujillo.
PY - 2019
Y1 - 2019
N2 - To establish differences in the genotoxic effect of particulate matter (PM10) in exposed individuals at two sites in the Valle de Aburrá (VA). This was a descriptive cross-sectional study of 2 groups of individuals exposed to 67.7 and 45 μg/m3 of PM10 for a minimum of 8 hours/day. The frequency of Chromosomal Abnormalities (CAs) and the mitotic index were evaluated based on blood samples. The data were processed using SPSS version 18.0 and significant differences were established between the groups at p<0.05. One hundred eighteen individuals were evaluated: 56.8% at site 1 and 43.2% at site 2. The study population had an average age of 53 years. Significant differences were found between the numbers of CAs (p = 0.003) detected at the sample sites. Site 1 displayed a higher number of CAs than site 2, likely because site 1 is located in an area of the VA that is more exposed to environmental contamination. Furthermore, this study showed that there is a relationship between the level of particulate matter and an increase in a biomarker for CAs, establishing a possible health risk in this population, especially for those who remain there for long periods of time.
AB - To establish differences in the genotoxic effect of particulate matter (PM10) in exposed individuals at two sites in the Valle de Aburrá (VA). This was a descriptive cross-sectional study of 2 groups of individuals exposed to 67.7 and 45 μg/m3 of PM10 for a minimum of 8 hours/day. The frequency of Chromosomal Abnormalities (CAs) and the mitotic index were evaluated based on blood samples. The data were processed using SPSS version 18.0 and significant differences were established between the groups at p<0.05. One hundred eighteen individuals were evaluated: 56.8% at site 1 and 43.2% at site 2. The study population had an average age of 53 years. Significant differences were found between the numbers of CAs (p = 0.003) detected at the sample sites. Site 1 displayed a higher number of CAs than site 2, likely because site 1 is located in an area of the VA that is more exposed to environmental contamination. Furthermore, this study showed that there is a relationship between the level of particulate matter and an increase in a biomarker for CAs, establishing a possible health risk in this population, especially for those who remain there for long periods of time.
KW - Air Pollutants
KW - Chromosome Aberrations
KW - DNA Damage
KW - Genotoxicity
KW - Mutagenesis
UR - http://www.scopus.com/inward/record.url?scp=85067409961&partnerID=8YFLogxK
U2 - 10.3844/ojbsci.2019.92.97
DO - 10.3844/ojbsci.2019.92.97
M3 - Artículo en revista científica indexada
AN - SCOPUS:85067409961
SN - 1608-4217
VL - 19
SP - 92
EP - 97
JO - OnLine Journal of Biological Sciences
JF - OnLine Journal of Biological Sciences
IS - 1
ER -