Infección por strongyloides stercoralis: Metanálisis sobre evaluación de métodos diagnósticos convencionales (1980-2013)

Laura Campo Polanco, Lina A. Gutiérrez, Jaiberth Cardona Arias

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

36 Citas (Scopus)

Resumen

Methods: Systematic review with meta-analysis, exhaustive and reproducible literature search of six databases. Quality of the articles was assessed and meta-analysis was performed under the random effects model, calculating sensitivity, specificity, likelihood ratios, predictive values, proportion of false results, accuracy, odds ratio and Youden index J and ROC curve using Meta-DiSc(es) and Epidat 3.1.

Background: Research on diagnostic methods have strongyloidiasis divergent validity and incomplete by not reporting data on safety, efficiency and performance diagnosis.

Objective: To assess validity, performance, efficiency and safety of four diagnostic conventional parasitological methods for detection of Strongyloides stercoralis infection in the period 1980-2013.

Results: 11 studies with 9,025 individuals were included. Sensitivity of the Baermann method was 72%, positive likelihood ratio (LR+) 228 and negative likelihood ratio (LR-) 0.32. The agar plate culture (APC) had a sensitivity of 89%, LR+ 341 and LR- 0.11. Stool sensitivity was 21%, LR+ 67 and LR- 0.67. Sensitivity of the formol-ether concentration was 48%, LR+ 110 and LR- 0.59. Areas under the ROC curve were 0.999 in Baermann and APC, 0.977 in the stool and 0.829 in formalin-ether concentration; specificity was 100% in all tests.

Conclusion: The four conventional parasitological methods tested in this study to detect S. stercoralis can be helpful; however, agar plate culture and Baermann method are best suited.

Título traducido de la contribuciónDiagnosis of strongyloides stercoralis infection. Meta-analysis on evaluation of conventional parasitological methods (1980-2013)
Idioma originalEspañol
Páginas (desde-hasta)581-600
Número de páginas20
PublicaciónRevista Espanola de Salud Publica
Volumen88
N.º5
DOI
EstadoPublicada - 1 sept. 2014
Publicado de forma externa

Palabras clave

  • Diagnostic validity
  • Efficiency
  • Evaluation
  • Safety
  • Strongyloides stercoralis
  • Strongyloidiasis

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