Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study protocol

James J. Crowley; Carolina Cappi; Marcos E. Ochoa-Panaifo; Renee M. Frederick; Minjee Kook; Andrew D. Wiese; Diana Rancourt; Elizabeth G. Atkinson; Paola Giusti-Rodriguez; Jacey L. Anderberg; Jonathan S. Abramowitz; Victor R. Adorno; Cinthia Aguirre; Gilberto S. Alves; Gustavo S. Alves; Na Eshia Ancalade; Alejandro A. Arellano Espinosa; Paul D. Arnold; Daphne M. Ayton; Izabela G. Barbosa; Laura Marcela Barón Castano; Cynthia N. Barrera; María Celeste Berardo; Dayan Berrones; John R. Best; Tim B. Bigdeli; Christie L. Burton; Joseph D. Buxbaum; Jennifer L. Callahan; Maria Cecília B. Carneiro; Sandra L. Cepeda; Evelyn Chazelle; Jessica M. Chire; Macarena Churruca Munoz; Pamela Claisse Quiroz; Journa Cobite; Jonathan S. Comer; Daniel L. Costa; Jennifer Crosbie; Victor O. Cruz; Guillermo Dager; Luisa F. Daza; Anabel de la Rosa-Gómez; Daniela del Río; Fernanda Z. Delage; Carolina B. Dreher; Lucila Fay; Tomas Fazio; Ygor A. Ferrão; Gabriela M. Ferreira; Edith G. Figueroa; Leonardo F. Fontenelle; Diego A. Forero; Daniele T.H. Fragoso; Bharathi S. Gadad; Sheldon R. Garrison; Andres González; Laura D. Gonzalez; Marco A. González; Polaris Gonzalez-Barrios; Wayne K. Goodman; Dorothy E. Grice; Jerry Guintivano; Daniel G. Guttfreund; Andrew G. Guzick; Matthew W. Halvorsen; Joseph D. Hovey; Hailiang Huang; Jonathan Irreño-Sotomonte; Reinhard Janssen-Aguilar; Matias Jensen; Alexandra Z. Jimenez Reynolds; Joali Alexandra Juárez Lujambio; Nasim Khalfe; Madison A. Knutsen; Caleb Lack; Nuria Lanzagorta; Monicke O. Lima; Melanie O. Longhurst; David A. Lozada Martinez; Elba S. Luna; Andrea H. Marques; Molly S. Martinez; Maria de Los Angeles Matos; Caitlyn E. Maye; Joseph F. McGuire; Gabriela Menezes; Charlene Minaya; Tomás Miño; Sara M. Mithani; Circe Montes de Oca; Alonso Morales-Rivero; Maria E. Moreira-de-Oliveira; Olivia J. Morris; Sandra I. Muñoz; Zainab Naqqash; Ambar A. Núñez Bracho; Belinda E. Núñez Bracho; Maria Corina Ochoa Rojas; Luis A. Olavarria Castaman; Trinidad Olivos Balmaceda; Iliana Ortega; Darpan I. Patel; Ainsley K. Patrick; Mariel Paz y Mino; Jose L. Perales Orellana; Bárbara Perdigão Stumpf; Tamara Peregrina; Tania Pérez Duarte; Kelly L. Piacsek; Maritza Placencia; María Belén Prieto; Lucas C. Quarantini; Yana Quarantini-Alvim; Renato T. Ramos; Iaroslava C. Ramos; Vanessa R. Ramos; Kesley A. Ramsey; Elise V. Ray; Margaret A. Richter; Bradley C. Riemann; Juan C. Rivas; Maria C. Rosario; Camilo J. Ruggero; Angel A. Ruiz-Chow; Alejandra Ruiz-Velasco; Melisa N. Sagarnaga; Aline S. Sampaio; Leonardo C. Saraiva; Russell J. Schachar; Sophie C. Schneider; Ethan J. Schweissing; Laura D. Seligman; Roseli G. Shavitt; Keaton J. Soileau; S. Evelyn Stewart; Shaina B. Storch; Emily R. Strouphauer; Vissente Tapia Cuevas; Kiara R. Timpano; Beatriz Treviño de la Garza; Alexie Vallejo-Silva; Javier Vargas-Medrano; María I. Vásquez; Guadalupe Vidal Martinez; Saira A. Weinzimmer; Mauricio A. Yanez; Gwyneth Zai; Lina M. Zapata-Restrepo; Luz M. Zappa; Raquel M. Zepeda-Burgos; Anthony W. Zoghbi; Euripedes C. Miguel; Carolyn I. Rodriguez; Mayra C. Martinez Mallen; Pablo R. Moya; Tania Borda; María Beatriz Moyano; Manuel Mattheisen; Stacey Pereira; Gabriel Lázaro-Muñoz; Karen G. Martinez-Gonzalez; Michele T. Pato; Humberto Nicolini; Eric A. Storch

doi:10.1002/ajmg.b.32962

Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study protocol

James J. Crowley, Carolina Cappi, Marcos E. Ochoa-Panaifo, Renee M. Frederick, Minjee Kook, Andrew D. Wiese, Diana Rancourt, Elizabeth G. Atkinson, Paola Giusti-Rodriguez, Jacey L. Anderberg, Jonathan S. Abramowitz, Victor R. Adorno, Cinthia Aguirre, Gilberto S. Alves, Gustavo S. Alves, Na Eshia Ancalade, Alejandro A. Arellano Espinosa, Paul D. Arnold, Daphne M. Ayton, Izabela G. BarbosaLaura Marcela Barón Castano, Cynthia N. Barrera, María Celeste Berardo, Dayan Berrones, John R. Best, Tim B. Bigdeli, Christie L. Burton, Joseph D. Buxbaum, Jennifer L. Callahan, Maria Cecília B. Carneiro, Sandra L. Cepeda, Evelyn Chazelle, Jessica M. Chire, Macarena Churruca Munoz, Pamela Claisse Quiroz, Journa Cobite, Jonathan S. Comer, Daniel L. Costa, Jennifer Crosbie, Victor O. Cruz, Guillermo Dager, Luisa F. Daza, Anabel de la Rosa-Gómez, Daniela del Río, Fernanda Z. Delage, Carolina B. Dreher, Lucila Fay, Tomas Fazio, Ygor A. Ferrão, Gabriela M. Ferreira, Edith G. Figueroa, Leonardo F. Fontenelle, Diego A. Forero, Daniele T.H. Fragoso, Bharathi S. Gadad, Sheldon R. Garrison, Andres González, Laura D. Gonzalez, Marco A. González, Polaris Gonzalez-Barrios, Wayne K. Goodman, Dorothy E. Grice, Jerry Guintivano, Daniel G. Guttfreund, Andrew G. Guzick, Matthew W. Halvorsen, Joseph D. Hovey, Hailiang Huang, Jonathan Irreño-Sotomonte, Reinhard Janssen-Aguilar, Matias Jensen, Alexandra Z. Jimenez Reynolds, Joali Alexandra Juárez Lujambio, Nasim Khalfe, Madison A. Knutsen, Caleb Lack, Nuria Lanzagorta, Monicke O. Lima, Melanie O. Longhurst, David A. Lozada Martinez, Elba S. Luna, Andrea H. Marques, Molly S. Martinez, Maria de Los Angeles Matos, Caitlyn E. Maye, Joseph F. McGuire, Gabriela Menezes, Charlene Minaya, Tomás Miño, Sara M. Mithani, Circe Montes de Oca, Alonso Morales-Rivero, Maria E. Moreira-de-Oliveira, Olivia J. Morris, Sandra I. Muñoz, Zainab Naqqash, Ambar A. Núñez Bracho, Belinda E. Núñez Bracho, Maria Corina Ochoa Rojas, Luis A. Olavarria Castaman, Trinidad Olivos Balmaceda, Iliana Ortega, Darpan I. Patel, Ainsley K. Patrick, Mariel Paz y Mino, Jose L. Perales Orellana, Bárbara Perdigão Stumpf, Tamara Peregrina, Tania Pérez Duarte, Kelly L. Piacsek, Maritza Placencia, María Belén Prieto, Lucas C. Quarantini, Yana Quarantini-Alvim, Renato T. Ramos, Iaroslava C. Ramos, Vanessa R. Ramos, Kesley A. Ramsey, Elise V. Ray, Margaret A. Richter, Bradley C. Riemann, Juan C. Rivas, Maria C. Rosario, Camilo J. Ruggero, Angel A. Ruiz-Chow, Alejandra Ruiz-Velasco, Melisa N. Sagarnaga, Aline S. Sampaio, Leonardo C. Saraiva, Russell J. Schachar, Sophie C. Schneider, Ethan J. Schweissing, Laura D. Seligman, Roseli G. Shavitt, Keaton J. Soileau, S. Evelyn Stewart, Shaina B. Storch, Emily R. Strouphauer, Vissente Tapia Cuevas, Kiara R. Timpano, Beatriz Treviño de la Garza, Alexie Vallejo-Silva, Javier Vargas-Medrano, María I. Vásquez, Guadalupe Vidal Martinez, Saira A. Weinzimmer, Mauricio A. Yanez, Gwyneth Zai, Lina M. Zapata-Restrepo, Luz M. Zappa, Raquel M. Zepeda-Burgos, Anthony W. Zoghbi, Euripedes C. Miguel, Carolyn I. Rodriguez, Mayra C. Martinez Mallen, Pablo R. Moya, Tania Borda, María Beatriz Moyano, Manuel Mattheisen, Stacey Pereira, Gabriel Lázaro-Muñoz, Karen G. Martinez-Gonzalez, Michele T. Pato, Humberto Nicolini, Eric A. Storch

Producción científica: Contribución a una revista › Artículo en revista científica indexada › revisión exhaustiva

Resumen

Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long-sought risk loci, but >95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics. In this study protocol paper, we describe the Latin American Trans-ancestry INitiative for OCD genomics (LATINO, https://www.latinostudy.org). LATINO is a new network of investigators from across Latin America, the United States, and Canada who have begun to collect DNA and clinical data from 5000 richly phenotyped OCD cases of Latin American ancestry in a culturally sensitive and ethical manner. In this project, we will utilize trans-ancestry genomic analyses to accelerate the identification of OCD risk loci, fine-map putative causal variants, and improve the performance of polygenic risk scores in diverse populations. We will also capitalize on rich clinical data to examine the genetics of treatment response, biologically plausible OCD subtypes, and symptom dimensions. Additionally, LATINO will help elucidate the diversity of the clinical presentations of OCD across cultures through various trainings developed and offered in collaboration with Latin American investigators. We believe this study will advance the important goal of global mental health discovery and equity.

Idioma original	Inglés
Publicación	American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
DOI	https://doi.org/10.1002/ajmg.b.32962
Estado	Aceptada/en prensa - 2023
Publicado de forma externa	Sí

Nota bibliográfica

Publisher Copyright:
© 2023 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics published by Wiley Periodicals LLC.

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

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Crowley, J. J., Cappi, C., Ochoa-Panaifo, M. E., Frederick, R. M., Kook, M., Wiese, A. D., Rancourt, D., Atkinson, E. G., Giusti-Rodriguez, P., Anderberg, J. L., Abramowitz, J. S., Adorno, V. R., Aguirre, C., Alves, G. S., Alves, G. S., Ancalade, N. E., Arellano Espinosa, A. A., Arnold, P. D., Ayton, D. M., ... Storch, E. A. (Aceptado/En prensa). Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study protocol. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. https://doi.org/10.1002/ajmg.b.32962

@article{98d6f0e266374b7387d82d8eb5d9a006,

title = "Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study protocol",

abstract = "Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long-sought risk loci, but >95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics. In this study protocol paper, we describe the Latin American Trans-ancestry INitiative for OCD genomics (LATINO, https://www.latinostudy.org). LATINO is a new network of investigators from across Latin America, the United States, and Canada who have begun to collect DNA and clinical data from 5000 richly phenotyped OCD cases of Latin American ancestry in a culturally sensitive and ethical manner. In this project, we will utilize trans-ancestry genomic analyses to accelerate the identification of OCD risk loci, fine-map putative causal variants, and improve the performance of polygenic risk scores in diverse populations. We will also capitalize on rich clinical data to examine the genetics of treatment response, biologically plausible OCD subtypes, and symptom dimensions. Additionally, LATINO will help elucidate the diversity of the clinical presentations of OCD across cultures through various trainings developed and offered in collaboration with Latin American investigators. We believe this study will advance the important goal of global mental health discovery and equity.",

keywords = "genetic, genomic, GWAS, Latin American, obsessive-compulsive disorder, OCD",

author = "Crowley, {James J.} and Carolina Cappi and Ochoa-Panaifo, {Marcos E.} and Frederick, {Renee M.} and Minjee Kook and Wiese, {Andrew D.} and Diana Rancourt and Atkinson, {Elizabeth G.} and Paola Giusti-Rodriguez and Anderberg, {Jacey L.} and Abramowitz, {Jonathan S.} and Adorno, {Victor R.} and Cinthia Aguirre and Alves, {Gilberto S.} and Alves, {Gustavo S.} and Ancalade, {Na Eshia} and {Arellano Espinosa}, {Alejandro A.} and Arnold, {Paul D.} and Ayton, {Daphne M.} and Barbosa, {Izabela G.} and Castano, {Laura Marcela Bar{\'o}n} and Barrera, {Cynthia N.} and Berardo, {Mar{\'i}a Celeste} and Dayan Berrones and Best, {John R.} and Bigdeli, {Tim B.} and Burton, {Christie L.} and Buxbaum, {Joseph D.} and Callahan, {Jennifer L.} and Carneiro, {Maria Cec{\'i}lia B.} and Cepeda, {Sandra L.} and Evelyn Chazelle and Chire, {Jessica M.} and Munoz, {Macarena Churruca} and Quiroz, {Pamela Claisse} and Journa Cobite and Comer, {Jonathan S.} and Costa, {Daniel L.} and Jennifer Crosbie and Cruz, {Victor O.} and Guillermo Dager and Daza, {Luisa F.} and {de la Rosa-G{\'o}mez}, Anabel and {del R{\'i}o}, Daniela and Delage, {Fernanda Z.} and Dreher, {Carolina B.} and Lucila Fay and Tomas Fazio and Ferr{\~a}o, {Ygor A.} and Ferreira, {Gabriela M.} and Figueroa, {Edith G.} and Fontenelle, {Leonardo F.} and Forero, {Diego A.} and Fragoso, {Daniele T.H.} and Gadad, {Bharathi S.} and Garrison, {Sheldon R.} and Andres Gonz{\'a}lez and Gonzalez, {Laura D.} and Gonz{\'a}lez, {Marco A.} and Polaris Gonzalez-Barrios and Goodman, {Wayne K.} and Grice, {Dorothy E.} and Jerry Guintivano and Guttfreund, {Daniel G.} and Guzick, {Andrew G.} and Halvorsen, {Matthew W.} and Hovey, {Joseph D.} and Hailiang Huang and Jonathan Irre{\~n}o-Sotomonte and Reinhard Janssen-Aguilar and Matias Jensen and {Jimenez Reynolds}, {Alexandra Z.} and Lujambio, {Joali Alexandra Ju{\'a}rez} and Nasim Khalfe and Knutsen, {Madison A.} and Caleb Lack and Nuria Lanzagorta and Lima, {Monicke O.} and Longhurst, {Melanie O.} and {Lozada Martinez}, {David A.} and Luna, {Elba S.} and Marques, {Andrea H.} and Martinez, {Molly S.} and {de Los Angeles Matos}, Maria and Maye, {Caitlyn E.} and McGuire, {Joseph F.} and Gabriela Menezes and Charlene Minaya and Tom{\'a}s Mi{\~n}o and Mithani, {Sara M.} and {de Oca}, {Circe Montes} and Alonso Morales-Rivero and Moreira-de-Oliveira, {Maria E.} and Morris, {Olivia J.} and Mu{\~n}oz, {Sandra I.} and Zainab Naqqash and {N{\'u}{\~n}ez Bracho}, {Ambar A.} and {N{\'u}{\~n}ez Bracho}, {Belinda E.} and Rojas, {Maria Corina Ochoa} and {Olavarria Castaman}, {Luis A.} and Balmaceda, {Trinidad Olivos} and Iliana Ortega and Patel, {Darpan I.} and Patrick, {Ainsley K.} and {Paz y Mino}, Mariel and {Perales Orellana}, {Jose L.} and Stumpf, {B{\'a}rbara Perdig{\~a}o} and Tamara Peregrina and Duarte, {Tania P{\'e}rez} and Piacsek, {Kelly L.} and Maritza Placencia and Prieto, {Mar{\'i}a Bel{\'e}n} and Quarantini, {Lucas C.} and Yana Quarantini-Alvim and Ramos, {Renato T.} and Ramos, {Iaroslava C.} and Ramos, {Vanessa R.} and Ramsey, {Kesley A.} and Ray, {Elise V.} and Richter, {Margaret A.} and Riemann, {Bradley C.} and Rivas, {Juan C.} and Rosario, {Maria C.} and Ruggero, {Camilo J.} and Ruiz-Chow, {Angel A.} and Alejandra Ruiz-Velasco and Sagarnaga, {Melisa N.} and Sampaio, {Aline S.} and Saraiva, {Leonardo C.} and Schachar, {Russell J.} and Schneider, {Sophie C.} and Schweissing, {Ethan J.} and Seligman, {Laura D.} and Shavitt, {Roseli G.} and Soileau, {Keaton J.} and Stewart, {S. Evelyn} and Storch, {Shaina B.} and Strouphauer, {Emily R.} and Cuevas, {Vissente Tapia} and Timpano, {Kiara R.} and {la Garza}, {Beatriz Trevi{\~n}o de} and Alexie Vallejo-Silva and Javier Vargas-Medrano and V{\'a}squez, {Mar{\'i}a I.} and Martinez, {Guadalupe Vidal} and Weinzimmer, {Saira A.} and Yanez, {Mauricio A.} and Gwyneth Zai and Zapata-Restrepo, {Lina M.} and Zappa, {Luz M.} and Zepeda-Burgos, {Raquel M.} and Zoghbi, {Anthony W.} and Miguel, {Euripedes C.} and Rodriguez, {Carolyn I.} and {Martinez Mallen}, {Mayra C.} and Moya, {Pablo R.} and Tania Borda and Moyano, {Mar{\'i}a Beatriz} and Manuel Mattheisen and Stacey Pereira and Gabriel L{\'a}zaro-Mu{\~n}oz and Martinez-Gonzalez, {Karen G.} and Pato, {Michele T.} and Humberto Nicolini and Storch, {Eric A.}",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics published by Wiley Periodicals LLC.",

year = "2023",

doi = "10.1002/ajmg.b.32962",

language = "Ingl{\'e}s",

journal = "American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics",

issn = "1552-4841",

publisher = "Wiley-Liss Inc.",

}

Crowley, JJ, Cappi, C, Ochoa-Panaifo, ME, Frederick, RM, Kook, M, Wiese, AD, Rancourt, D, Atkinson, EG, Giusti-Rodriguez, P, Anderberg, JL, Abramowitz, JS, Adorno, VR, Aguirre, C, Alves, GS, Alves, GS, Ancalade, NE, Arellano Espinosa, AA, Arnold, PD, Ayton, DM, Barbosa, IG, Castano, LMB, Barrera, CN, Berardo, MC, Berrones, D, Best, JR, Bigdeli, TB, Burton, CL, Buxbaum, JD, Callahan, JL, Carneiro, MCB, Cepeda, SL, Chazelle, E, Chire, JM, Munoz, MC, Quiroz, PC, Cobite, J, Comer, JS, Costa, DL, Crosbie, J, Cruz, VO, Dager, G, Daza, LF, de la Rosa-Gómez, A, del Río, D, Delage, FZ, Dreher, CB, Fay, L, Fazio, T, Ferrão, YA, Ferreira, GM, Figueroa, EG, Fontenelle, LF, Forero, DA, Fragoso, DTH, Gadad, BS, Garrison, SR, González, A, Gonzalez, LD, González, MA, Gonzalez-Barrios, P, Goodman, WK, Grice, DE, Guintivano, J, Guttfreund, DG, Guzick, AG, Halvorsen, MW, Hovey, JD, Huang, H, Irreño-Sotomonte, J, Janssen-Aguilar, R, Jensen, M, Jimenez Reynolds, AZ, Lujambio, JAJ, Khalfe, N, Knutsen, MA, Lack, C, Lanzagorta, N, Lima, MO, Longhurst, MO, Lozada Martinez, DA, Luna, ES, Marques, AH, Martinez, MS, de Los Angeles Matos, M, Maye, CE, McGuire, JF, Menezes, G, Minaya, C, Miño, T, Mithani, SM, de Oca, CM, Morales-Rivero, A, Moreira-de-Oliveira, ME, Morris, OJ, Muñoz, SI, Naqqash, Z, Núñez Bracho, AA, Núñez Bracho, BE, Rojas, MCO, Olavarria Castaman, LA, Balmaceda, TO, Ortega, I, Patel, DI, Patrick, AK, Paz y Mino, M, Perales Orellana, JL, Stumpf, BP, Peregrina, T, Duarte, TP, Piacsek, KL, Placencia, M, Prieto, MB, Quarantini, LC, Quarantini-Alvim, Y, Ramos, RT, Ramos, IC, Ramos, VR, Ramsey, KA, Ray, EV, Richter, MA, Riemann, BC, Rivas, JC, Rosario, MC, Ruggero, CJ, Ruiz-Chow, AA, Ruiz-Velasco, A, Sagarnaga, MN, Sampaio, AS, Saraiva, LC, Schachar, RJ, Schneider, SC, Schweissing, EJ, Seligman, LD, Shavitt, RG, Soileau, KJ, Stewart, SE, Storch, SB, Strouphauer, ER, Cuevas, VT, Timpano, KR, la Garza, BTD, Vallejo-Silva, A, Vargas-Medrano, J, Vásquez, MI, Martinez, GV, Weinzimmer, SA, Yanez, MA, Zai, G, Zapata-Restrepo, LM, Zappa, LM, Zepeda-Burgos, RM, Zoghbi, AW, Miguel, EC, Rodriguez, CI, Martinez Mallen, MC, Moya, PR, Borda, T, Moyano, MB, Mattheisen, M, Pereira, S, Lázaro-Muñoz, G, Martinez-Gonzalez, KG, Pato, MT, Nicolini, H & Storch, EA 2023, 'Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study protocol', American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. https://doi.org/10.1002/ajmg.b.32962

TY - JOUR

T1 - Latin American Trans-ancestry INitiative for OCD genomics (LATINO)

T2 - Study protocol

AU - Crowley, James J.

AU - Cappi, Carolina

AU - Ochoa-Panaifo, Marcos E.

AU - Frederick, Renee M.

AU - Kook, Minjee

AU - Wiese, Andrew D.

AU - Rancourt, Diana

AU - Atkinson, Elizabeth G.

AU - Giusti-Rodriguez, Paola

AU - Anderberg, Jacey L.

AU - Abramowitz, Jonathan S.

AU - Adorno, Victor R.

AU - Aguirre, Cinthia

AU - Alves, Gilberto S.

AU - Alves, Gustavo S.

AU - Ancalade, Na Eshia

AU - Arellano Espinosa, Alejandro A.

AU - Arnold, Paul D.

AU - Ayton, Daphne M.

AU - Barbosa, Izabela G.

AU - Castano, Laura Marcela Barón

AU - Barrera, Cynthia N.

AU - Berardo, María Celeste

AU - Berrones, Dayan

AU - Best, John R.

AU - Bigdeli, Tim B.

AU - Burton, Christie L.

AU - Buxbaum, Joseph D.

AU - Callahan, Jennifer L.

AU - Carneiro, Maria Cecília B.

AU - Cepeda, Sandra L.

AU - Chazelle, Evelyn

AU - Chire, Jessica M.

AU - Munoz, Macarena Churruca

AU - Quiroz, Pamela Claisse

AU - Cobite, Journa

AU - Comer, Jonathan S.

AU - Costa, Daniel L.

AU - Crosbie, Jennifer

AU - Cruz, Victor O.

AU - Dager, Guillermo

AU - Daza, Luisa F.

AU - de la Rosa-Gómez, Anabel

AU - del Río, Daniela

AU - Delage, Fernanda Z.

AU - Dreher, Carolina B.

AU - Fay, Lucila

AU - Fazio, Tomas

AU - Ferrão, Ygor A.

AU - Ferreira, Gabriela M.

AU - Figueroa, Edith G.

AU - Fontenelle, Leonardo F.

AU - Forero, Diego A.

AU - Fragoso, Daniele T.H.

AU - Gadad, Bharathi S.

AU - Garrison, Sheldon R.

AU - González, Andres

AU - Gonzalez, Laura D.

AU - González, Marco A.

AU - Gonzalez-Barrios, Polaris

AU - Goodman, Wayne K.

AU - Grice, Dorothy E.

AU - Guintivano, Jerry

AU - Guttfreund, Daniel G.

AU - Guzick, Andrew G.

AU - Halvorsen, Matthew W.

AU - Hovey, Joseph D.

AU - Huang, Hailiang

AU - Irreño-Sotomonte, Jonathan

AU - Janssen-Aguilar, Reinhard

AU - Jensen, Matias

AU - Jimenez Reynolds, Alexandra Z.

AU - Lujambio, Joali Alexandra Juárez

AU - Khalfe, Nasim

AU - Knutsen, Madison A.

AU - Lack, Caleb

AU - Lanzagorta, Nuria

AU - Lima, Monicke O.

AU - Longhurst, Melanie O.

AU - Lozada Martinez, David A.

AU - Luna, Elba S.

AU - Marques, Andrea H.

AU - Martinez, Molly S.

AU - de Los Angeles Matos, Maria

AU - Maye, Caitlyn E.

AU - McGuire, Joseph F.

AU - Menezes, Gabriela

AU - Minaya, Charlene

AU - Miño, Tomás

AU - Mithani, Sara M.

AU - de Oca, Circe Montes

AU - Morales-Rivero, Alonso

AU - Moreira-de-Oliveira, Maria E.

AU - Morris, Olivia J.

AU - Muñoz, Sandra I.

AU - Naqqash, Zainab

AU - Núñez Bracho, Ambar A.

AU - Núñez Bracho, Belinda E.

AU - Rojas, Maria Corina Ochoa

AU - Olavarria Castaman, Luis A.

AU - Balmaceda, Trinidad Olivos

AU - Ortega, Iliana

AU - Patel, Darpan I.

AU - Patrick, Ainsley K.

AU - Paz y Mino, Mariel

AU - Perales Orellana, Jose L.

AU - Stumpf, Bárbara Perdigão

AU - Peregrina, Tamara

AU - Duarte, Tania Pérez

AU - Piacsek, Kelly L.

AU - Placencia, Maritza

AU - Prieto, María Belén

AU - Quarantini, Lucas C.

AU - Quarantini-Alvim, Yana

AU - Ramos, Renato T.

AU - Ramos, Iaroslava C.

AU - Ramos, Vanessa R.

AU - Ramsey, Kesley A.

AU - Ray, Elise V.

AU - Richter, Margaret A.

AU - Riemann, Bradley C.

AU - Rivas, Juan C.

AU - Rosario, Maria C.

AU - Ruggero, Camilo J.

AU - Ruiz-Chow, Angel A.

AU - Ruiz-Velasco, Alejandra

AU - Sagarnaga, Melisa N.

AU - Sampaio, Aline S.

AU - Saraiva, Leonardo C.

AU - Schachar, Russell J.

AU - Schneider, Sophie C.

AU - Schweissing, Ethan J.

AU - Seligman, Laura D.

AU - Shavitt, Roseli G.

AU - Soileau, Keaton J.

AU - Stewart, S. Evelyn

AU - Storch, Shaina B.

AU - Strouphauer, Emily R.

AU - Cuevas, Vissente Tapia

AU - Timpano, Kiara R.

AU - la Garza, Beatriz Treviño de

AU - Vallejo-Silva, Alexie

AU - Vargas-Medrano, Javier

AU - Vásquez, María I.

AU - Martinez, Guadalupe Vidal

AU - Weinzimmer, Saira A.

AU - Yanez, Mauricio A.

AU - Zai, Gwyneth

AU - Zapata-Restrepo, Lina M.

AU - Zappa, Luz M.

AU - Zepeda-Burgos, Raquel M.

AU - Zoghbi, Anthony W.

AU - Miguel, Euripedes C.

AU - Rodriguez, Carolyn I.

AU - Martinez Mallen, Mayra C.

AU - Moya, Pablo R.

AU - Borda, Tania

AU - Moyano, María Beatriz

AU - Mattheisen, Manuel

AU - Pereira, Stacey

AU - Lázaro-Muñoz, Gabriel

AU - Martinez-Gonzalez, Karen G.

AU - Pato, Michele T.

AU - Nicolini, Humberto

AU - Storch, Eric A.

PY - 2023

Y1 - 2023

N2 - Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long-sought risk loci, but >95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics. In this study protocol paper, we describe the Latin American Trans-ancestry INitiative for OCD genomics (LATINO, https://www.latinostudy.org). LATINO is a new network of investigators from across Latin America, the United States, and Canada who have begun to collect DNA and clinical data from 5000 richly phenotyped OCD cases of Latin American ancestry in a culturally sensitive and ethical manner. In this project, we will utilize trans-ancestry genomic analyses to accelerate the identification of OCD risk loci, fine-map putative causal variants, and improve the performance of polygenic risk scores in diverse populations. We will also capitalize on rich clinical data to examine the genetics of treatment response, biologically plausible OCD subtypes, and symptom dimensions. Additionally, LATINO will help elucidate the diversity of the clinical presentations of OCD across cultures through various trainings developed and offered in collaboration with Latin American investigators. We believe this study will advance the important goal of global mental health discovery and equity.

AB - Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long-sought risk loci, but >95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics. In this study protocol paper, we describe the Latin American Trans-ancestry INitiative for OCD genomics (LATINO, https://www.latinostudy.org). LATINO is a new network of investigators from across Latin America, the United States, and Canada who have begun to collect DNA and clinical data from 5000 richly phenotyped OCD cases of Latin American ancestry in a culturally sensitive and ethical manner. In this project, we will utilize trans-ancestry genomic analyses to accelerate the identification of OCD risk loci, fine-map putative causal variants, and improve the performance of polygenic risk scores in diverse populations. We will also capitalize on rich clinical data to examine the genetics of treatment response, biologically plausible OCD subtypes, and symptom dimensions. Additionally, LATINO will help elucidate the diversity of the clinical presentations of OCD across cultures through various trainings developed and offered in collaboration with Latin American investigators. We believe this study will advance the important goal of global mental health discovery and equity.

KW - genetic

KW - genomic

KW - GWAS

KW - Latin American

KW - obsessive-compulsive disorder

KW - OCD

UR - http://www.scopus.com/inward/record.url?scp=85176913852&partnerID=8YFLogxK

U2 - 10.1002/ajmg.b.32962

DO - 10.1002/ajmg.b.32962

M3 - Artículo en revista científica indexada

C2 - 37946624

AN - SCOPUS:85176913852

SN - 1552-4841

JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

ER -

Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study protocol

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