Legionella co-infection in HIV-associated pneumonia

Breanne M. Head, Adriana Trajtman, Kathryn Bernard, Tamara Burdz, Lázaro Vélez, Mariana Herrera, Zulma Vanessa Rueda, Yoav Keynan

Producción científica: Contribución a una revistaArtículo en revista científica indexadarevisión exhaustiva

10 Citas (Scopus)

Resumen

Due to poor diagnostics and increased co-infections, HIV-associated Legionella infections are underreported. We aimed to retrospectively determine the frequency of Legionella infections in bronchoalveolar lavage (BAL) from HIV-associated pneumonia patients hospitalized in Medellin, Colombia, between February 2007 and April 2014. Although culture was negative, 17 BAL (36%) were positive for Legionella by quantitative polymerase chain reaction, most of which were in the Mycobacterium tuberculosis or Pneumocystis jirovecii co-infected patients, and included L. anisa (n = 6), L. bozemanae (n = 4), L. pneumophila (n = 3), and L. micdadei (n = 2). All L. bozemanae and L. micdadei associated with Pneumocystis, while all L. pneumophila associated with M. tuberculosis. Legionella probable cases had more complications and higher mortality rates (P = 0.02) and were rarely administered empirical anti-Legionella therapy while in hospital. Clinicians should be aware of the possible presence of Legionella in HIV and M. tuberculosis or P. jirovecii co-infected patients.
Idioma originalEspañol (Colombia)
Páginas (desde-hasta)71-76
Número de páginas6
PublicaciónDiagnostic Microbiology and Infectious Disease
Volumen95
N.º1
DOI
EstadoPublicada - 2019
Publicado de forma externa

Palabras clave

  • Bronchoalveolar lavage
  • Co-infection
  • HIV
  • Legionella
  • Pneumonia

Tipos de Productos Minciencias

  • Artículos de investigación con calidad A1 / Q1

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