Manifestaciones clínicas y paraclínicas de la hepatitis autoinmune en 48 pacientes de la ciudad de Medellín, 1980-2004

Marcos Arango Barrientos, Juan Camilo Díaz Coronado, Juan Carlos Ortega Castrillón, Julio César Restrepo Zapata, Gonzalo Correa Arango, Juan Carlos Restrepo Gutiérrez, Jorge Hernando Donado Gómez

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

2 Citas (Scopus)

Resumen

Objective: To describe the clinical, biochemical, histological, sociodemographical and therapeutic aspects of patients with autoimmune hepatitis (AIH). Methods: Descriptive, retrospective, case series trial in 48 patients from the city of Medellín with a diagnosis of AIH according to the criteria from the International Autoimmune Hepatitis Group. Results: Average age at the time of diagnosis was 34 years, 83.3% were females. The most frequent clinical findings were fatigue (89.6%) and jaundice (81.3%). The pretreatment median of laboratory findings were: AST 626 U/L, ALT 547.5 U/L, total bilirubin 5.64 mg/dL, direct bilirubin 3.4 mg/dL. Posttreatment median values were: AST 40.5 U/L, ALT 44.4 U/L, total bilirubin 1.1 mg/dL, direct bilirubin 0.4 mg/dL (p <0.000). The average value of the gammaglobulins was 2.2 g/dL; in 81.3% of the patients a liver biopsy was performed and 97.4% of them had histological findings consistent with AIH. Forty patients had positive antinuclear antibodies. In 19 patients concurrent autoimmune diseases were found, most frequently thyroiditis. The most frequently administered treatment was the combination of prednisone plus azathioprine in 56.3% of the cases; 85.4% of the patients entered in remission and 25% had a relapse. Conclusions: The sociodemographical characteristics of our patients differ from those of other series The clinical, biochemical and histological findings are similar to those reported in the medical literature; however, this was not observed with the associated autoimmune diseases. Most patients belonged to the subtype 1 of the disease.

Título traducido de la contribuciónClinical and paraclinical manifestations of autoimmune hepatitis in 48 patients from Medellín, Colombia
Idioma originalEspañol
Páginas (desde-hasta)160-166
Número de páginas7
PublicaciónIatreia
Volumen18
N.º2
EstadoPublicada - jun. 2005
Publicado de forma externa

Palabras clave

  • Autoimmune hepatitis
  • Autoimmunity

Huella

Profundice en los temas de investigación de 'Manifestaciones clínicas y paraclínicas de la hepatitis autoinmune en 48 pacientes de la ciudad de Medellín, 1980-2004'. En conjunto forman una huella única.

Citar esto