Manifestaciones cutáneas de lupus eritematoso sistémico temprano y correlación con la actividad sistémica

Carlos Jaime Velásquez Franco, Andrés Anaya Prada, Libia María Rodríguez Padilla, Francisco Iván Vargas Grajales, Luis Alberto Ramírez Gómez

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

1 Cita (Scopus)

Resumen

Cutaneous manifestations of systemic lupus erythematosus (SLE) are heterogeneous (both specific and non-specific). Little is known about the relationship between these manifestations and the clinical and immunological activity of the disease in early stages. We carried out a cross-sectional study in 34 patients with early SLE. We found a significant association between alopecia and hypocomplementemia C3 (p = 0.021), hypocomplementemia C4 (p < 0.001) and anti-Sm (p = 0.011); between malar erythema and anti-Ro (p = 0.037) and anti-La (p = 0.037); between photosensitivity and anti-RNP (p = 0.037). We observed a trend to association between oral ulcers and hypocomplementemia C4 (p = 0.064). No association was found between cutaneous manifestations and the presence of anti-ds DNA, anticardiolipin antibodies, lupus anticoagulant, false-positive VDRL, leucopenia, thrombocytopenia, hypergammaglobulinemia, elevated erythrosedimentation rate or SLEDAI. We highlight the relevance of the relationship between non-specific cutaneous manifestations of early SLE (alopecia and photosensitivity) and the systemic activity of the disease and hypocomplementemia, an important marker of immunological activity.

Título traducido de la contribuciónCutaneous manifestations of early systemic lupus erythematosus and correlation with systemic activity
Idioma originalEspañol
Páginas (desde-hasta)359-364
Número de páginas6
PublicaciónIatreia
Volumen24
N.º4
EstadoPublicada - 2011
Publicado de forma externa

Palabras clave

  • Alopecia
  • Complement C3
  • Complement C4
  • Cutaneous
  • Lupus erythematosus
  • Systemic

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