Resumen
Objectives
Describe maternal, fetal and neonatal outcomes in singleton pregnancies with diagnosis of fetal growth restriction (FGR) and hypertensive disorders in pregnancy.
Methods
Cohort study in patients with FGR and associated with hypertensive disorders in a maternal-fetal referral centre in Medellin, Colombia, between May 2018 to February 2020. Patients with other comorbidities and fetuses with congenital abnormalities were excluded. FGR was classified according to the onset in early < 32 and late ≥ 32 weeks. Data on maternal outcomes until discharge, perinatal and neonatal outcomes until 28 days after birth was obtained and groups were compared.
Results
65 pregnancies were included. Then mean age of diagnosis was 31 weeks (IQR 27–33), 55,4% (36/65) early and 44,6% (29/65) late FGR. Patients were diagnosed with gestational hypertension in 16,9% (11/5), chronic hypertension with superimposed PE (pre-eclampsia) in 13,8% (9/65), non-severe PE 18,5% (12/65) and severe PE 50,8% (33/65), Hellp syndrome in 18,5% (12/65) and eclampsia in 3,1% (2/65). Mothers were admitted to ICU in 41,5% (27/65) and used antihypertensive drugs in 72,3% (47/65). Most pregnancies ended because of PE 66.2% (43/65) and 70,7% (46/65) were delivered by Caesarean. The average birthweight was 1,618 gr (SD 630,9), with Apgar < 7 at 5 minutes 10,8 % (7/65). At birth 60% (39/65) required NICU and the main neonatal morbidity was respiratory distress syndrome 33,8% (22/65) with perinatal mortality 6,1% (4/65) and neonatal mortality 3,1% (2/65).
Conclusions
The coexistence of hypertensive disorders and early FGR represents a greater probability of longer hospital stays (p = 0,018), maternal admission to ICU (p = 0,005) and use of antihypertensive drugs (p = 0,010) than patients with late FGR. Furthermore, fetuses with early FGR had higher morbidity and mortality, higher Caesarean section rates (p = 0,007) and longer stays in NICU (p = <0,0001) than late FGR.
Describe maternal, fetal and neonatal outcomes in singleton pregnancies with diagnosis of fetal growth restriction (FGR) and hypertensive disorders in pregnancy.
Methods
Cohort study in patients with FGR and associated with hypertensive disorders in a maternal-fetal referral centre in Medellin, Colombia, between May 2018 to February 2020. Patients with other comorbidities and fetuses with congenital abnormalities were excluded. FGR was classified according to the onset in early < 32 and late ≥ 32 weeks. Data on maternal outcomes until discharge, perinatal and neonatal outcomes until 28 days after birth was obtained and groups were compared.
Results
65 pregnancies were included. Then mean age of diagnosis was 31 weeks (IQR 27–33), 55,4% (36/65) early and 44,6% (29/65) late FGR. Patients were diagnosed with gestational hypertension in 16,9% (11/5), chronic hypertension with superimposed PE (pre-eclampsia) in 13,8% (9/65), non-severe PE 18,5% (12/65) and severe PE 50,8% (33/65), Hellp syndrome in 18,5% (12/65) and eclampsia in 3,1% (2/65). Mothers were admitted to ICU in 41,5% (27/65) and used antihypertensive drugs in 72,3% (47/65). Most pregnancies ended because of PE 66.2% (43/65) and 70,7% (46/65) were delivered by Caesarean. The average birthweight was 1,618 gr (SD 630,9), with Apgar < 7 at 5 minutes 10,8 % (7/65). At birth 60% (39/65) required NICU and the main neonatal morbidity was respiratory distress syndrome 33,8% (22/65) with perinatal mortality 6,1% (4/65) and neonatal mortality 3,1% (2/65).
Conclusions
The coexistence of hypertensive disorders and early FGR represents a greater probability of longer hospital stays (p = 0,018), maternal admission to ICU (p = 0,005) and use of antihypertensive drugs (p = 0,010) than patients with late FGR. Furthermore, fetuses with early FGR had higher morbidity and mortality, higher Caesarean section rates (p = 0,007) and longer stays in NICU (p = <0,0001) than late FGR.
| Idioma original | Inglés |
|---|---|
| Publicación | Ultrasound in Obstetrics and Gynecology |
| Volumen | 56 |
| DOI | |
| Estado | Publicada - oct. 2020 |
Tipos de Productos Minciencias
- Eventos científicos con componente de apropiación