Mortality predictors in critically ill patients with severe COVID-19 pneumonia: A multicenter observational study in Colombia

Título traducido de la contribución: Predictores de mortalidad en pacientes críticos con neumonía grave por coronavirus 2019 (COVID-19): un estudio observacional multicéntrico en Colombia

Francisco José Molina, Luz Elena Botero, Juan Pablo Isaza, Lucelly López, Marco Antonio González, Bladimir Alejandro Gil, Juan Luis Echeverri, Juan David Uribe, Victoria E. Ángel, Nelson Javier Fonseca, Sindy Sitton, Aurelio González, Juan Miguel Arias, Francisco Luis Zapata, Jhon Alexander Gallego, Ana Sofía Cortés, Daniel Giraldo, Andrea Mazo, Catalina Aguilar, Valentina RuizJuan José Molina, Isabella Vélez, Luisa María García, Darcy Dariani Archbold, Paula Andrea Alarcón, Leidy Tamayo, Lina Marcela Hoyos, Juan Pablo Acosta, Luisa María Escobar, Antoni Torres

    Producción científica: Contribución a una revistaArtículo en revista científica indexadarevisión exhaustiva

    Resumen

    Introduction: Patients on invasive mechanical ventilation (IMV) with COVID-19 have a high mortality. There is a lack of information on the factors associated with mortality in these patients with a hospital stay of less than 48 hours, which reflects the severity of the disease. Objective: To identify the variables associated with mortality in patients admitted to the intensive care unit (ICU) in IMV with severe pneumonia due to COVID-19. Materials and methods: Prospective study conducted from March 1 to July 30, 2021, in nine ICUs in the city of Medellín, Colombia. Adult patients who required IMV upon admission to the ICU, with a hospital stay of less than 48 hours, were included. The following variables were studied: personal history, laboratory tests, complications during the stay, and medical treatment. A multivariate analysis was performed in a Poisson regression model with robust errors. Results: Of the 148 patients admitted to the study, 35.8% died. The risk factors related to mortality in the multivariate analysis were: older than 65 years [RR 2.15 (1.36 - 3.41)], continuing with IMV on day 7 of stay [RR 3.13 (1, 13 – 8.69)], and a history of chronic kidney disease [RR 2.09 (1.2 - 3.64)]. Patients with a C-reactive protein value greater than 10 mg/dL had lower mortality [RR 0.65 (0.44 – 0.95)]. Conclusions: Continuing IMV on day 7, being over 65 years of age, or chronic kidney disease were the risk factors associated with mortality.

    Título traducido de la contribuciónPredictores de mortalidad en pacientes críticos con neumonía grave por coronavirus 2019 (COVID-19): un estudio observacional multicéntrico en Colombia
    Idioma originalInglés
    PublicaciónActa Colombiana de Cuidado Intensivo
    DOI
    EstadoAceptada/en prensa - 2024

    Nota bibliográfica

    Publisher Copyright:
    © 2023 Asociación Colombiana de Medicina Crítica y Cuidado lntensivo

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