TY - JOUR
T1 - Mutations in DNA repair genes are associated with the Haarlem lineage of Mycobacterium tuberculosis independently of their antibiotic resistance
AU - Olano, Juanita
AU - López, Beatriz
AU - Reyes, Alejandro
AU - del Pilar Lemos, María
AU - Correa, Nidia
AU - Del Portillo, Patricia
AU - Barrera, Lucia
AU - Robledo, Jaime
AU - Ritacco, Viviana
AU - Mercedes Zambrano, María
N1 - Funding Information:
This work was partially funded by Colciencias (No. 65700418076 and RC No. 431-2004), SeCyT (PICT No. 05-09978) and the European Commission (EC-LSHP-CT-516028).
PY - 2007/11
Y1 - 2007/11
N2 - The analysis of the DNA repair genes ogt and ung was carried out in 117 Mycobacterium tuberculosis clinical isolates from Argentina and Colombia in order to explore correlation between mutations in these genes and multi-drug resistance. With the exception of two Beijing family isolates, the rest of the strains harbored either two wild-type or two mutant alleles with identical single nucleotide polymorphisms (SNPs) in each gene (ogt44 and ung501). These ogt44 and ung501 mutations were not associated with multi-drug resistance and occurred simultaneously in circulating Haarlem genotype M. tuberculosis strains. We therefore propose the use of these markers as tools in phylogenetic and epidemiologic studies.
AB - The analysis of the DNA repair genes ogt and ung was carried out in 117 Mycobacterium tuberculosis clinical isolates from Argentina and Colombia in order to explore correlation between mutations in these genes and multi-drug resistance. With the exception of two Beijing family isolates, the rest of the strains harbored either two wild-type or two mutant alleles with identical single nucleotide polymorphisms (SNPs) in each gene (ogt44 and ung501). These ogt44 and ung501 mutations were not associated with multi-drug resistance and occurred simultaneously in circulating Haarlem genotype M. tuberculosis strains. We therefore propose the use of these markers as tools in phylogenetic and epidemiologic studies.
KW - DNA repair enzymes
KW - Multi-drug resistant tuberculosis
KW - Mycobacterium tuberculosis
KW - Single nucleotide polymorphism
UR - http://www.scopus.com/inward/record.url?scp=35348887751&partnerID=8YFLogxK
U2 - 10.1016/j.tube.2007.05.011
DO - 10.1016/j.tube.2007.05.011
M3 - Artículo en revista científica indexada
C2 - 17919978
AN - SCOPUS:35348887751
SN - 1472-9792
VL - 87
SP - 502
EP - 508
JO - Tuberculosis
JF - Tuberculosis
IS - 6
ER -