Mutations in DNA repair genes are associated with the Haarlem lineage of Mycobacterium tuberculosis independently of their antibiotic resistance

Juanita Olano, Beatriz López, Alejandro Reyes, María del Pilar Lemos, Nidia Correa, Patricia Del Portillo, Lucia Barrera, Jaime Robledo, Viviana Ritacco, María Mercedes Zambrano

    Producción científica: Contribución a una revistaArtículo en revista científica indexadarevisión exhaustiva

    20 Citas (Scopus)

    Resumen

    The analysis of the DNA repair genes ogt and ung was carried out in 117 Mycobacterium tuberculosis clinical isolates from Argentina and Colombia in order to explore correlation between mutations in these genes and multi-drug resistance. With the exception of two Beijing family isolates, the rest of the strains harbored either two wild-type or two mutant alleles with identical single nucleotide polymorphisms (SNPs) in each gene (ogt44 and ung501). These ogt44 and ung501 mutations were not associated with multi-drug resistance and occurred simultaneously in circulating Haarlem genotype M. tuberculosis strains. We therefore propose the use of these markers as tools in phylogenetic and epidemiologic studies.

    Idioma originalInglés
    Páginas (desde-hasta)502-508
    Número de páginas7
    PublicaciónTuberculosis
    Volumen87
    N.º6
    DOI
    EstadoPublicada - nov. 2007

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