Mycoplasma pneumoniae in children with and without community-acquired Pneumonia. What do PCR and serology say?

Angela Rocio Copete, Angela Rocio Copete, Cristian Vera, Cristian Vera, Mariana Herrera, Mariana Herrera, Yudy Alexandra Aguilar, Zulma Vanessa Rueda, Lázaro Agustín Vélez

    Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

    5 Citas (Scopus)

    Resumen

    Background: IgM titers of Mycoplasma pneumoniae can remain high for months or years, and specific DNA can be detected in asymptomatic people. Methods: We compared the performance of serology and PCR in children with and without community-acquired pneumonia (CAP) for the diagnosis of M. pneumoniae. Results: In children with CAP, a positive test by M. pneumoniae (PCR and/or paired serology or both) were found in 13.9%. Of these, 10.3% were positive by multiplex PCR (Seeplex-Seegen), and 6.7% exhibited quadrupled titers (22 for IgG, 6 for IgM and 5 for both). Both tests were positive in 2.8% of cases. In the group without CAP, 3.3% were positive by PCR. Thirty-two percent of children with CAP and 38.3% of healthy children had IgM titers >11 in the acute phase. Conclusions: The detection of IgM is not useful for diagnosing acute M. pneumoniae infection, and a positive PCR result can be due to colonization and not infection. New and better diagnostic techniques are required.

    Idioma originalInglés
    Páginas (desde-hasta)E104-E108
    PublicaciónPediatric Infectious Disease Journal
    DOI
    EstadoAceptada/en prensa - 2020

    Nota bibliográfica

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    © 2020 Wolters Kluwer Health, Inc. All rights reserved.

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