TY - JOUR
T1 - Variants in candidate genes and their interactions with smoking on the risk of acute coronary syndrome
AU - Valencia, Diana María
AU - Martínez Gutiérrez, Carlos Andrés
AU - Saldarriaga, Clara
AU - Arango-Viana, Juan Carlos
AU - Gonzalez-Jaramillo, Nathalia
AU - Garcia, Jenny
AU - Valencia Duarte, Ana Victoria
A2 - Franco-Hincapié, Liliana
A2 - Gallego Lopera, Berta Natalia
A2 - Velarde-Hoyos, Cristian Arbey
A2 - Pérez-Bedoya, Juan Pablo
A2 - Betancur-Salazar, Kelly Johanna
A2 - Marisancén-Carrasquilla, Kelly
A2 - Carvalho, Santiago
A2 - Cotes, Evert Jiménez
A2 - Parra Rodas, Luisa María
PY - 2024/10/24
Y1 - 2024/10/24
N2 - Introduction. Multiple genetic and environmental factors interact with the development of acute coronary syndrome (ACS); smoking is one of the environmental factors that might alter the metabolic pathways common to genes associated with this condition. Objective. To investigate the association of genetic variants related to inflammation, lipid metabolism, and platelet aggregation on ACS in subjects from the northeast of Colombia. The effects of interactions between polymorphisms and smoking were also evaluated. Materials and methods. Data were analyzed for 330 ACS cases and 430 controls. Associations at 20 polymorphisms with ACS were evaluated using logistic regression adjusted by confounders. Gene-smoking interaction terms were calculated, and variants were analyzed in association with ACS separately in “smokers” and “non-smokers. Results. Two variants were associated with ACS, rs10455872 (LPA) (OR=2.69; 95%CI=1.61-4.49) and rs429358 (APOE) (OR=1.93; 95%CI=1.30-2.87). We identified gene-smoking interactions for the variants rs6511720 (LDLR) (p=0.04) and rs2227631 (SERPINE1) (p=0.02), we observed significant effects between non-smokers (rs6511720 OR=0.40; 95%CI=0.19.-0.88, and rs2227631 OR=0.69; 95%CI=0.48-1.00), but not in smokers (rs6511720 OR=1.28; 95%CI=0.66-2.46, and rs2227631 OR=1.30; 95%CI=0.91-1.87). Conclusions. Variants in the candidate genes LPA and APOE are associated with a higher risk of ACS in a population from the northeast of Colombia. The effects of rs6511720 (LDLR) and rs2227631 (SERPINE1) differ according to smoking habits and are significant in non-smokers. These results are helpful for early screening of ACS risks, mainly in individuals whose conventional risk factors have not been yet elucidated.
AB - Introduction. Multiple genetic and environmental factors interact with the development of acute coronary syndrome (ACS); smoking is one of the environmental factors that might alter the metabolic pathways common to genes associated with this condition. Objective. To investigate the association of genetic variants related to inflammation, lipid metabolism, and platelet aggregation on ACS in subjects from the northeast of Colombia. The effects of interactions between polymorphisms and smoking were also evaluated. Materials and methods. Data were analyzed for 330 ACS cases and 430 controls. Associations at 20 polymorphisms with ACS were evaluated using logistic regression adjusted by confounders. Gene-smoking interaction terms were calculated, and variants were analyzed in association with ACS separately in “smokers” and “non-smokers. Results. Two variants were associated with ACS, rs10455872 (LPA) (OR=2.69; 95%CI=1.61-4.49) and rs429358 (APOE) (OR=1.93; 95%CI=1.30-2.87). We identified gene-smoking interactions for the variants rs6511720 (LDLR) (p=0.04) and rs2227631 (SERPINE1) (p=0.02), we observed significant effects between non-smokers (rs6511720 OR=0.40; 95%CI=0.19.-0.88, and rs2227631 OR=0.69; 95%CI=0.48-1.00), but not in smokers (rs6511720 OR=1.28; 95%CI=0.66-2.46, and rs2227631 OR=1.30; 95%CI=0.91-1.87). Conclusions. Variants in the candidate genes LPA and APOE are associated with a higher risk of ACS in a population from the northeast of Colombia. The effects of rs6511720 (LDLR) and rs2227631 (SERPINE1) differ according to smoking habits and are significant in non-smokers. These results are helpful for early screening of ACS risks, mainly in individuals whose conventional risk factors have not been yet elucidated.
KW - Acute coronary syndrome
KW - genetic association studies
KW - gene-environment interactions
KW - smoking
U2 - https://revistabiomedica.org/index.php/biomedica/article/view/7379
DO - https://revistabiomedica.org/index.php/biomedica/article/view/7379
M3 - Artículo en revista científica indexada
VL - 45
JO - Biomedica : revista del Instituto Nacional de Salud
JF - Biomedica : revista del Instituto Nacional de Salud
IS - 1
ER -