Variants in candidate genes and their interactions with smoking on the risk of acute coronary syndrome

Liliana Franco-Hincapié; Berta Natalia Gallego Lopera; Cristian Arbey Velarde-Hoyos; Diana María Valencia; Juan Pablo Pérez-Bedoya; Kelly Johanna Betancur-Salazar; Kelly Marisancén-Carrasquilla; Santiago Carvalho; Evert Jiménez Cotes; Luisa María Parra Rodas; Carlos Andrés Martínez Gutiérrez; Clara Saldarriaga; Juan Carlos Arango-Viana; Nathalia Gonzalez-Jaramillo; Jenny Garcia; Ana Victoria Valencia Duarte

doi:https://revistabiomedica.org/index.php/biomedica/article/view/7379

Variants in candidate genes and their interactions with smoking on the risk of acute coronary syndrome

Título traducido de la contribución: Variantes de genes candidatos y su interacción con el hábito de fumar sobre el riesgo de síndrome coronario agudo

Liliana Franco-Hincapié (Autor estudiante de doctorado), Berta Natalia Gallego Lopera (Autor estudiante de doctorado), Cristian Arbey Velarde-Hoyos (Autor estudiante de maestría), Diana María Valencia, Juan Pablo Pérez-Bedoya (Autor estudiante de pregrado), Kelly Johanna Betancur-Salazar (Autor estudiante de maestría), Kelly Marisancén-Carrasquilla (Autor estudiante de pregrado), Santiago Carvalho (Autor estudiante de pregrado), Evert Jiménez Cotes (Autor estudiante de pregrado), Luisa María Parra Rodas (Autor estudiante de pregrado), Carlos Andrés Martínez Gutiérrez, Clara Saldarriaga, Juan Carlos Arango-Viana, Nathalia Gonzalez-Jaramillo, Jenny Garcia, Ana Victoria Valencia Duarte

Biología de Sistemas

Producción científica: Contribución a una revista › Artículo en revista científica indexada › revisión exhaustiva

Resumen

Introduction. Multiple genetic and environmental factors interact with the development of acute coronary syndrome. Smoking is one of the environmental factors that might alter the metabolic pathways shared by genes associated with this condition. Objective. To investigate the association of acute coronary syndrome with genetic variants related to inflammation, lipid metabolism, and platelet aggregation among subjects from the northeastern region of Colombia. The effects of interactions between polymorphisms and smoking were also evaluated. Materials and methods. We analyzed data from 330 acute coronary syndrome cases and 430 controls. Associations between 20 polymorphisms and acute coronary syndrome were evaluated using logistic regression, adjusting for confounders. Gene and smoking interaction terms were calculated, and variants were analyzed separately in smokers and non-smokers for their association with acute coronary syndrome. Results. Two variants were associated with acute coronary syndrome, rs10455872 in the LPA gene (OR = 2.69; 95% CI: 1.61–4.49) and rs429358 in the APOE gene (OR = 1.93; 95% CI: 1.30–2.87). We identified smoking interactions with the variants rs6511720 in the LDLR gene (p = 0.04) and rs2227631 in the SERPINE1 gene (p = 0.02), with significant effects in non-smokers (rs6511720: OR = 0.40; 95% CI: 0.19–0.88; and rs2227631: OR = 0.69; 95% CI: 0.48–1.00), but not in smokers (rs6511720: OR = 1.28; 95% CI: 0.66–2.46; and rs2227631: OR = 1.30; 95% CI: 0.91–1.87). Conclusions. Variants in the candidate genes LPA and APOE are associated with an increased risk of acute coronary syndrome in a population from northeastern Colombia. The effects of rs6511720 in LDLR and rs2227631 in SERPINE1 differ according to smoking habits and are significant in non-smokers. These results are helpful for early risk screening of acute coronary syndrome, mainly in individuals without defined conventional risk factors.

Título traducido de la contribución	Variantes de genes candidatos y su interacción con el hábito de fumar sobre el riesgo de síndrome coronario agudo
Idioma original	Inglés
Páginas (desde-hasta)	107-117
Número de páginas	11
Publicación	Biomedica
Volumen	45
N.º	1
DOI	https://doi.org/https://revistabiomedica.org/index.php/biomedica/article/view/7379 https://doi.org/10.7705/biomedica.7379
Estado	Publicada - 2025

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Publisher Copyright:
© (2025), (Instituto Nacional de Salud). All rights reserved.

Palabras clave

Acute coronary syndrome
genetic association studies
gene-environment interactions
smoking

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Artículos de investigación con calidad Q3

ODS de las Naciones Unidas

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https://revistabiomedica.org/index.php/biomedica/article/view/7379

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Franco-Hincapié, L., Gallego Lopera, B. N., Velarde-Hoyos, C. A., Valencia, D. M., Pérez-Bedoya, J. P., Betancur-Salazar, K. J., Marisancén-Carrasquilla, K., Carvalho, S., Cotes, E. J., Parra Rodas, L. M., Martínez Gutiérrez, C. A., Saldarriaga, C., Arango-Viana, J. C., Gonzalez-Jaramillo, N., Garcia, J., & Valencia Duarte, A. V. (2025). Variants in candidate genes and their interactions with smoking on the risk of acute coronary syndrome. Biomedica, 45(1), 107-117. https://doi.org/https://revistabiomedica.org/index.php/biomedica/article/view/7379, https://doi.org/10.7705/biomedica.7379

@article{1ea0c5612c524a35a6b849ea3c4ebaf5,

title = "Variants in candidate genes and their interactions with smoking on the risk of acute coronary syndrome",

abstract = "Introduction. Multiple genetic and environmental factors interact with the development of acute coronary syndrome. Smoking is one of the environmental factors that might alter the metabolic pathways shared by genes associated with this condition. Objective. To investigate the association of acute coronary syndrome with genetic variants related to inflammation, lipid metabolism, and platelet aggregation among subjects from the northeastern region of Colombia. The effects of interactions between polymorphisms and smoking were also evaluated. Materials and methods. We analyzed data from 330 acute coronary syndrome cases and 430 controls. Associations between 20 polymorphisms and acute coronary syndrome were evaluated using logistic regression, adjusting for confounders. Gene and smoking interaction terms were calculated, and variants were analyzed separately in smokers and non-smokers for their association with acute coronary syndrome. Results. Two variants were associated with acute coronary syndrome, rs10455872 in the LPA gene (OR = 2.69; 95% CI: 1.61–4.49) and rs429358 in the APOE gene (OR = 1.93; 95% CI: 1.30–2.87). We identified smoking interactions with the variants rs6511720 in the LDLR gene (p = 0.04) and rs2227631 in the SERPINE1 gene (p = 0.02), with significant effects in non-smokers (rs6511720: OR = 0.40; 95% CI: 0.19–0.88; and rs2227631: OR = 0.69; 95% CI: 0.48–1.00), but not in smokers (rs6511720: OR = 1.28; 95% CI: 0.66–2.46; and rs2227631: OR = 1.30; 95% CI: 0.91–1.87). Conclusions. Variants in the candidate genes LPA and APOE are associated with an increased risk of acute coronary syndrome in a population from northeastern Colombia. The effects of rs6511720 in LDLR and rs2227631 in SERPINE1 differ according to smoking habits and are significant in non-smokers. These results are helpful for early risk screening of acute coronary syndrome, mainly in individuals without defined conventional risk factors.",

keywords = "Acute coronary syndrome, genetic association studies, gene-environment interactions, smoking",

author = "Liliana Franco-Hincapi{\'e} and {Gallego Lopera}, {Berta Natalia} and Velarde-Hoyos, {Cristian Arbey} and Valencia, {Diana Mar{\'i}a} and P{\'e}rez-Bedoya, {Juan Pablo} and Betancur-Salazar, {Kelly Johanna} and Kelly Marisanc{\'e}n-Carrasquilla and Santiago Carvalho and Cotes, {Evert Jim{\'e}nez} and {Parra Rodas}, {Luisa Mar{\'i}a} and {Mart{\'i}nez Guti{\'e}rrez}, {Carlos Andr{\'e}s} and Clara Saldarriaga and Arango-Viana, {Juan Carlos} and Nathalia Gonzalez-Jaramillo and Jenny Garcia and {Valencia Duarte}, {Ana Victoria}",

year = "2025",

doi = "https://revistabiomedica.org/index.php/biomedica/article/view/7379",

language = "Ingl{\'e}s",

volume = "45",

pages = "107--117",

journal = "Biomedica",

issn = "0120-4157",

publisher = "Instituto Nacional de Salud",

number = "1",

}

Franco-Hincapié, L, Gallego Lopera, BN, Velarde-Hoyos, CA, Valencia, DM, Pérez-Bedoya, JP, Betancur-Salazar, KJ, Marisancén-Carrasquilla, K, Carvalho, S, Cotes, EJ, Parra Rodas, LM, Martínez Gutiérrez, CA, Saldarriaga, C, Arango-Viana, JC, Gonzalez-Jaramillo, N, Garcia, J & Valencia Duarte, AV 2025, 'Variants in candidate genes and their interactions with smoking on the risk of acute coronary syndrome', Biomedica, vol. 45, n.º 1, pp. 107-117. https://doi.org/https://revistabiomedica.org/index.php/biomedica/article/view/7379, https://doi.org/10.7705/biomedica.7379

Variants in candidate genes and their interactions with smoking on the risk of acute coronary syndrome. / Franco-Hincapié, Liliana (Autor estudiante de doctorado); Gallego Lopera, Berta Natalia (Autor estudiante de doctorado); Velarde-Hoyos, Cristian Arbey (Autor estudiante de maestría) et al.
En: Biomedica, Vol. 45, N.º 1, 2025, p. 107-117.

Producción científica: Contribución a una revista › Artículo en revista científica indexada › revisión exhaustiva

TY - JOUR

T1 - Variants in candidate genes and their interactions with smoking on the risk of acute coronary syndrome

AU - Valencia, Diana María

AU - Martínez Gutiérrez, Carlos Andrés

AU - Saldarriaga, Clara

AU - Arango-Viana, Juan Carlos

AU - Gonzalez-Jaramillo, Nathalia

AU - Garcia, Jenny

AU - Valencia Duarte, Ana Victoria

A2 - Franco-Hincapié, Liliana

A2 - Gallego Lopera, Berta Natalia

A2 - Velarde-Hoyos, Cristian Arbey

A2 - Pérez-Bedoya, Juan Pablo

A2 - Betancur-Salazar, Kelly Johanna

A2 - Marisancén-Carrasquilla, Kelly

A2 - Carvalho, Santiago

A2 - Cotes, Evert Jiménez

A2 - Parra Rodas, Luisa María

PY - 2025

Y1 - 2025

N2 - Introduction. Multiple genetic and environmental factors interact with the development of acute coronary syndrome. Smoking is one of the environmental factors that might alter the metabolic pathways shared by genes associated with this condition. Objective. To investigate the association of acute coronary syndrome with genetic variants related to inflammation, lipid metabolism, and platelet aggregation among subjects from the northeastern region of Colombia. The effects of interactions between polymorphisms and smoking were also evaluated. Materials and methods. We analyzed data from 330 acute coronary syndrome cases and 430 controls. Associations between 20 polymorphisms and acute coronary syndrome were evaluated using logistic regression, adjusting for confounders. Gene and smoking interaction terms were calculated, and variants were analyzed separately in smokers and non-smokers for their association with acute coronary syndrome. Results. Two variants were associated with acute coronary syndrome, rs10455872 in the LPA gene (OR = 2.69; 95% CI: 1.61–4.49) and rs429358 in the APOE gene (OR = 1.93; 95% CI: 1.30–2.87). We identified smoking interactions with the variants rs6511720 in the LDLR gene (p = 0.04) and rs2227631 in the SERPINE1 gene (p = 0.02), with significant effects in non-smokers (rs6511720: OR = 0.40; 95% CI: 0.19–0.88; and rs2227631: OR = 0.69; 95% CI: 0.48–1.00), but not in smokers (rs6511720: OR = 1.28; 95% CI: 0.66–2.46; and rs2227631: OR = 1.30; 95% CI: 0.91–1.87). Conclusions. Variants in the candidate genes LPA and APOE are associated with an increased risk of acute coronary syndrome in a population from northeastern Colombia. The effects of rs6511720 in LDLR and rs2227631 in SERPINE1 differ according to smoking habits and are significant in non-smokers. These results are helpful for early risk screening of acute coronary syndrome, mainly in individuals without defined conventional risk factors.

AB - Introduction. Multiple genetic and environmental factors interact with the development of acute coronary syndrome. Smoking is one of the environmental factors that might alter the metabolic pathways shared by genes associated with this condition. Objective. To investigate the association of acute coronary syndrome with genetic variants related to inflammation, lipid metabolism, and platelet aggregation among subjects from the northeastern region of Colombia. The effects of interactions between polymorphisms and smoking were also evaluated. Materials and methods. We analyzed data from 330 acute coronary syndrome cases and 430 controls. Associations between 20 polymorphisms and acute coronary syndrome were evaluated using logistic regression, adjusting for confounders. Gene and smoking interaction terms were calculated, and variants were analyzed separately in smokers and non-smokers for their association with acute coronary syndrome. Results. Two variants were associated with acute coronary syndrome, rs10455872 in the LPA gene (OR = 2.69; 95% CI: 1.61–4.49) and rs429358 in the APOE gene (OR = 1.93; 95% CI: 1.30–2.87). We identified smoking interactions with the variants rs6511720 in the LDLR gene (p = 0.04) and rs2227631 in the SERPINE1 gene (p = 0.02), with significant effects in non-smokers (rs6511720: OR = 0.40; 95% CI: 0.19–0.88; and rs2227631: OR = 0.69; 95% CI: 0.48–1.00), but not in smokers (rs6511720: OR = 1.28; 95% CI: 0.66–2.46; and rs2227631: OR = 1.30; 95% CI: 0.91–1.87). Conclusions. Variants in the candidate genes LPA and APOE are associated with an increased risk of acute coronary syndrome in a population from northeastern Colombia. The effects of rs6511720 in LDLR and rs2227631 in SERPINE1 differ according to smoking habits and are significant in non-smokers. These results are helpful for early risk screening of acute coronary syndrome, mainly in individuals without defined conventional risk factors.

KW - Acute coronary syndrome

KW - genetic association studies

KW - gene-environment interactions

KW - smoking

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U2 - https://revistabiomedica.org/index.php/biomedica/article/view/7379

DO - https://revistabiomedica.org/index.php/biomedica/article/view/7379

M3 - Artículo en revista científica indexada

C2 - 40257950

AN - SCOPUS:105002396045

SN - 0120-4157

VL - 45

SP - 107

EP - 117

JO - Biomedica

JF - Biomedica

IS - 1

ER -

Variants in candidate genes and their interactions with smoking on the risk of acute coronary syndrome

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ODS de las Naciones Unidas

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