Variants in candidate genes and their interactions with smoking on the risk of acute coronary syndrome

Título traducido de la contribución: Variantes en genes candidatos y su interacción con fumar sobre el riesgo de síndrome coronario agudo

Liliana Franco-Hincapié (Autor estudiante de doctorado), Berta Natalia Gallego Lopera (Autor estudiante de doctorado), Cristian Arbey Velarde-Hoyos (Autor estudiante de maestría), Diana María Valencia, Juan Pablo Pérez-Bedoya (Autor estudiante de pregrado), Kelly Johanna Betancur-Salazar (Autor estudiante de maestría), Kelly Marisancén-Carrasquilla (Autor estudiante de pregrado), Santiago Carvalho (Autor estudiante de pregrado), Evert Jiménez Cotes (Autor estudiante de pregrado), Luisa María Parra Rodas (Autor estudiante de pregrado), Carlos Andrés Martínez Gutiérrez, Clara Saldarriaga, Juan Carlos Arango-Viana, Nathalia Gonzalez-Jaramillo, Jenny Garcia, Ana Victoria Valencia Duarte

Producción científica: Contribución a una revistaArtículo en revista científica indexadarevisión exhaustiva

Resumen

Introduction. Multiple genetic and environmental factors interact with the development of acute coronary syndrome (ACS); smoking is one of the environmental factors that might alter the metabolic pathways common to genes associated with this condition. Objective. To investigate the association of genetic variants related to inflammation, lipid metabolism, and platelet aggregation on ACS in subjects from the northeast of Colombia. The effects of interactions between polymorphisms and smoking were also evaluated. Materials and methods. Data were analyzed for 330 ACS cases and 430 controls. Associations at 20 polymorphisms with ACS were evaluated using logistic regression adjusted by confounders. Gene-smoking interaction terms were calculated, and variants were analyzed in association with ACS separately in “smokers” and “non-smokers. Results. Two variants were associated with ACS, rs10455872 (LPA) (OR=2.69; 95%CI=1.61-4.49) and rs429358 (APOE) (OR=1.93; 95%CI=1.30-2.87). We identified gene-smoking interactions for the variants rs6511720 (LDLR) (p=0.04) and rs2227631 (SERPINE1) (p=0.02), we observed significant effects between non-smokers (rs6511720 OR=0.40; 95%CI=0.19.-0.88, and rs2227631 OR=0.69; 95%CI=0.48-1.00), but not in smokers (rs6511720 OR=1.28; 95%CI=0.66-2.46, and rs2227631 OR=1.30; 95%CI=0.91-1.87). Conclusions. Variants in the candidate genes LPA and APOE are associated with a higher risk of ACS in a population from the northeast of Colombia. The effects of rs6511720 (LDLR) and rs2227631 (SERPINE1) differ according to smoking habits and are significant in non-smokers. These results are helpful for early screening of ACS risks, mainly in individuals whose conventional risk factors have not been yet elucidated.
Título traducido de la contribuciónVariantes en genes candidatos y su interacción con fumar sobre el riesgo de síndrome coronario agudo
Idioma originalInglés
PublicaciónBiomedica : revista del Instituto Nacional de Salud
Volumen45
N.º1
DOI
EstadoPublicada - 24 oct. 2024

Palabras clave

  • Acute coronary syndrome
  • genetic association studies
  • gene-environment interactions
  • smoking

Tipos de Productos Minciencias

  • Artículos de investigación con calidad Q3

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