Pharmacokinetics and pharmacodynamics of antibiotics in the critically ill patient: Part Two

Francisco Molina; Carlos Andrés Agudelo; Nelson Fonseca; Alicia Hidrón Botero; Carlos Andrés Jiménez; Álvaro Ochoa; Carlos Andrés Restrepo; Iván Mauricio Trompa; Gustavo Roncancio

doi:10.1016/j.acci.2015.11.001

Pharmacokinetics and pharmacodynamics of antibiotics in the critically ill patient: Part Two

Título traducido de la contribución: Farmacocinética y farmacodinamia de los antibióticos en el paciente críticamente enfermo. Segunda parte

Francisco Molina, Carlos Andrés Agudelo, Nelson Fonseca, Alicia Hidrón Botero, Carlos Andrés Jiménez, Álvaro Ochoa, Carlos Andrés Restrepo, Iván Mauricio Trompa, Gustavo Roncancio

Producción científica: Contribución a una revista › Estudio breve › revisión exhaustiva

Resumen

The development of antibiotic dosing regimens that adhere to the PK/PD principles may prolong the clinical lifespan of our existing antibiotics by reducing the emergence of resistance. This article presents a summary of the relevance of PK/PD characteristics of different antibiotic classes on the development of antibiotic resistance. On the basis of the available data, dosing recommendations are proposed that can be adopted in the clinical setting, in order to maximise therapeutic success and limit the emergence of resistance in intensive care units.

Título traducido de la contribución	Farmacocinética y farmacodinamia de los antibióticos en el paciente críticamente enfermo. Segunda parte
Idioma original	Inglés
Páginas (desde-hasta)	156-171
Número de páginas	16
Publicación	Acta Colombiana de Cuidado Intensivo
Volumen	16
N.º	3
DOI	https://doi.org/10.1016/j.acci.2015.11.001
Estado	Publicada - 1 jul. 2016

Nota bibliográfica

Publisher Copyright:
© 2015 Asociación Colombiana de Medicina Crítica y Cuidado lntensivo

Acceder al documento

10.1016/j.acci.2015.11.001

Citar esto

@article{d6943a2832cb4401b9d283cbabab1ce2,

title = "Pharmacokinetics and pharmacodynamics of antibiotics in the critically ill patient: Part Two",

abstract = "The development of antibiotic dosing regimens that adhere to the PK/PD principles may prolong the clinical lifespan of our existing antibiotics by reducing the emergence of resistance. This article presents a summary of the relevance of PK/PD characteristics of different antibiotic classes on the development of antibiotic resistance. On the basis of the available data, dosing recommendations are proposed that can be adopted in the clinical setting, in order to maximise therapeutic success and limit the emergence of resistance in intensive care units.",

keywords = "Bacterial resistance, Critical illness, Pharmacodynamics, Pharmacokinetics",

author = "Francisco Molina and Agudelo, {Carlos Andr{\'e}s} and Nelson Fonseca and Botero, {Alicia Hidr{\'o}n} and Jim{\'e}nez, {Carlos Andr{\'e}s} and {\'A}lvaro Ochoa and Restrepo, {Carlos Andr{\'e}s} and Trompa, {Iv{\'a}n Mauricio} and Gustavo Roncancio",

note = "Publisher Copyright: {\textcopyright} 2015 Asociaci{\'o}n Colombiana de Medicina Cr{\'i}tica y Cuidado lntensivo",

year = "2016",

month = jul,

day = "1",

doi = "10.1016/j.acci.2015.11.001",

language = "Ingl{\'e}s",

volume = "16",

pages = "156--171",

journal = "Acta Colombiana de Cuidado Intensivo",

issn = "0122-7262",

publisher = "Asociacion Colombiana de Medicina Critica y Cuidado lntensivo",

number = "3",

}

TY - JOUR

T1 - Pharmacokinetics and pharmacodynamics of antibiotics in the critically ill patient

T2 - Part Two

AU - Molina, Francisco

AU - Agudelo, Carlos Andrés

AU - Fonseca, Nelson

AU - Botero, Alicia Hidrón

AU - Jiménez, Carlos Andrés

AU - Ochoa, Álvaro

AU - Restrepo, Carlos Andrés

AU - Trompa, Iván Mauricio

AU - Roncancio, Gustavo

PY - 2016/7/1

Y1 - 2016/7/1

N2 - The development of antibiotic dosing regimens that adhere to the PK/PD principles may prolong the clinical lifespan of our existing antibiotics by reducing the emergence of resistance. This article presents a summary of the relevance of PK/PD characteristics of different antibiotic classes on the development of antibiotic resistance. On the basis of the available data, dosing recommendations are proposed that can be adopted in the clinical setting, in order to maximise therapeutic success and limit the emergence of resistance in intensive care units.

AB - The development of antibiotic dosing regimens that adhere to the PK/PD principles may prolong the clinical lifespan of our existing antibiotics by reducing the emergence of resistance. This article presents a summary of the relevance of PK/PD characteristics of different antibiotic classes on the development of antibiotic resistance. On the basis of the available data, dosing recommendations are proposed that can be adopted in the clinical setting, in order to maximise therapeutic success and limit the emergence of resistance in intensive care units.

KW - Bacterial resistance

KW - Critical illness

KW - Pharmacodynamics

KW - Pharmacokinetics

UR - http://www.scopus.com/inward/record.url?scp=85140580823&partnerID=8YFLogxK

U2 - 10.1016/j.acci.2015.11.001

DO - 10.1016/j.acci.2015.11.001

M3 - Estudio breve

AN - SCOPUS:85140580823

SN - 0122-7262

VL - 16

SP - 156

EP - 171

JO - Acta Colombiana de Cuidado Intensivo

JF - Acta Colombiana de Cuidado Intensivo

IS - 3

ER -

Pharmacokinetics and pharmacodynamics of antibiotics in the critically ill patient: Part Two

Resumen

Nota bibliográfica

Acceder al documento

Huella

Citar esto