Potential of Angiotensin-(1-7) in COVID-19 Treatment

Patricia Luna, María Fernanda Pérez, Jairo Castellar-Lopez, Aileen Chang, Yuliet Montoya, John Bustamante, Wendy Rosales-Rada, Evelyn Mendoza-Torres

Producción científica: Contribución a una revistaArtículo en revista científica indexadarevisión exhaustiva

3 Citas (Scopus)

Resumen

The new coronavirus currently named SARS-CoV-2 was announced by the World Health Organization as the virus causing the COVID-19 pandemic. The pathogenesis of SARS-CoV-2 initiates upon contact of a structural spike protein with the angiotensin II-converting enzyme receptor, leading to the induction of inflammatory mechanisms and progression to severe disease in some cases. Currently, studies have emerged linking COVID-19 with angiotensin-(1-7), demonstrating the potential of angiotensin-(1-7)/Mas Receptor axis induction to control disease severity due to its anti-inflammatory, vasodilator, antioxidant, antiproliferative, anticoagulant, antiangiogenic and fibrosis inhibitory effects. The renin angiotensin-system peptide Angiotensin-(1-7) shows a high therapeutic potential for COVID-19 mainly because of its ability to counteract the adverse effects caused in various organs due to angiotensin II-converting enzyme blockade. In light of these factors, the use of convalescent plasma conjugated therapy and Ang (1-7) agonists for the treatment of COVID-19 patients could be recommended. The differential expression of ACE2 and the varied response to SARS-CoV-2 are thought to be connected. According to several investigations, ACE2 antibodies and pharmacological inhibitors might be used to prevent viral entry. Given its capacity to eliminate the virus while ensuring lung and cardiovascular protection by regulating the inflammatory response, angiotensin-(1-7) is expected to be a safe choice. However, more clinical evidence is required to clarify the therapeutic usage of this peptide. The aim of this review article is to present an update of scientific data and clinical trials on the therapeutic potential of angiotensin-(1-7) in patients with COVID-19.
Idioma originalEspañol (Colombia)
Páginas (desde-hasta)89-97
Número de páginas9
PublicaciónCurrent Protein & Peptide Science
Volumen24
N.º1
DOI
EstadoPublicada - feb. 2022

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  • Artículos de investigación con calidad A2 / Q2

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