Radioquimioterapia preoperatoria en el carcinoma de recto

M. Tejedor, J. J. Valerdi, F. Molina, H. Ortiz, A. Adrian, M. De Miguel, J. Herrera

Producción científica: Contribución a una revistaArtículo en revista científica indexadarevisión exhaustiva


Purpose: The optimal treatment of large rectal cancer remains controversial. In this study we evaluated the tolerance of preoperative chemoradiotherapy and the impact on the staging and resectability. Material and method: From 1991 to 1995 sixty-three patients with biopsy proven rectal adenocarcinoma > 3 cms, involving the entire rectal wall and without metastases, were entered into the study. Radiotherapy with a total doses of 45 Gy, at 1.8 Gy/day, was administered on whole pelvic volume. Concomitant 5-Fluorouracil (300 mg/m2/day by I.V. bolus injection) was given for days 15 and 21-25 of radiotherapy. Results: Hematological toxicity grade I-II (OMS) was observed in 6 patients (9.5%); dysuria grade I-II in 10 patients (16%); diarrhea-tenesmus grade I-II in 15 patients (24%) and grade III in 4 patients (6%). Three patients refused surgery; in five patients (8%) the complete tumor resection was not possible (3 with unresectable tumor and 2 with abdominal disease); 42 patients (70%) underwent low anterior resection and 13 (22%) abdominoperineal resection. Pathological examination of the surgical specimen (n = 55) revealed: 8 patients with sterile specimen (14.5%); 9 with stage A (16.5%); 12 with stage B1 (22%); 16 stage B2 (29%) and 10 stage C (18%). Conclusion: Preoperative chemoradiation showed acceptable toxicity and enhanced the rates of downstaging and sphynctersparing surgery.

Título traducido de la contribuciónPreoperative radio-chemotherapy for rectal cancer
Idioma originalEspañol
Páginas (desde-hasta)51-55
Número de páginas5
EstadoPublicada - 1997
Publicado de forma externa

Palabras clave

  • chemoradiotherapy
  • preoperative
  • rectal cancer


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