Recent advances in polymer nanomaterials for drug delivery of adjuvants in colorectal cancer treatment: A scientific-technological analysis and review

Marlon Osorio, Estefanía Martinez, Tonny Naranjo, Cristina Castro

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

6 Citas (Scopus)

Resumen

Colorectal cancer (CRC) is the type with the second highest morbidity. Recently, a great number of bioactive compounds and encapsulation techniques have been developed. Thus, this paper aims to review the drug delivery strategies for chemotherapy adjuvant treatments for CRC, including an initial scientific-technological analysis of the papers and patents related to cancer, CRC, and adjuvant treatments. For 2018, a total of 167,366 cancer-related papers and 306,240 patents were found. Adjuvant treatments represented 39.3% of the total CRC patents, indicating the importance of adjuvants in the prognosis of patients. Chemotherapy adjuvants can be divided into two groups, natural and synthetic (5-fluorouracil and derivatives). Both groups can be encapsulated using polymers. Polymer-based drug delivery systems can be classified according to polymer nature. From those, anionic polymers have garnered the most attention, because they are pH responsive. The use of polymers tailors the desorption profile, improving drug bioavailability and enhancing the local treatment of CRC via oral administration. Finally, it can be concluded that antioxidants are emerging compounds that can complement today’s chemotherapy treatments. In the long term, encapsulated antioxidants will replace synthetic drugs and will play an important role in curing CRC.

Idioma originalInglés
Número de artículo2270
PublicaciónMolecules (Basel, Switzerland)
Volumen25
N.º10
DOI
EstadoPublicada - may. 2020

Nota bibliográfica

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

Huella

Profundice en los temas de investigación de 'Recent advances in polymer nanomaterials for drug delivery of adjuvants in colorectal cancer treatment: A scientific-technological analysis and review'. En conjunto forman una huella única.

Citar esto