Riesgoen niñosdeexpuestosinfección ay tuberculosisprogresión deenlaelenfermedadhogar, Colombia

Dione Benjumea Bedoya, Diana M. Marín, Jaime Robledo, Luis F. Barrera, Lucelly López, Helena Del Corral, Beatriz E. Ferro, Sonia L. Villegas, María Lilia Díaz, Carlos A. Rojas, Luis F. García, María P. Arbeláez

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

1 Cita (Scopus)

Resumen

Aim: To assess the risk of tuberculosis (infection and disease) in children less than 15 years’ old who are household contacts of pulmonary tubercul03osis patients in three Colombian cities (Medellín, Cali, and Popayán). Methods: A cohort of 1,040 children household contacts of 380 adults with smear-positive pulmonary tuberculosis was followed up for 24 months. Study period 2005-2009. Results: Tuberculin skin test was positive (≥10 mm) in 43.7% (95% CI: 39.2-48.2). Tuberculin skin test positivity was associated with age 10-14 years (Prevalence Ratio-PR= 1.43, 95% CI: 1.1-1.9), having a BCG vaccine scar (PR= 1.52, 95% CI: 1.1-2.1), underweight, closer proximity to the index case and exposure time >3 months. The annual risk of infection (tuberculin skin test induration increase of 6 mm or more per year) was 17% (95% CI: 11.8-22.2) and was associated with a bacillary load of the adult index case (Relative Risk-RR= 2.12, 95% CI: 1.0-4.3). The incidence rate of active tuberculosis was 12.4 cases per 1,000 persons-year. Children <5 years without BCG vaccine scar had a greater risk of developing active disease (Hazard Ratio-HR= 6.00, 95% CI: 1.3-28.3) than those with scar (HR= 1.33, 95% CI: 0.5-3.4). The risk of developing active tuberculosis augmented along with the increase from initial tuberculin skin test (tuberculin skin test 5-9 mm HR= 8.55, 95% CI: 2.5-29.2; tuberculin skin test ≥10 mm HR= 8.16, 95% CI: 2.0-32.9). Conclusions: There is a need for prompt interruption of adult-to-children tuberculosis transmission within households. Conducting proper contact investigation and offering chemoprophylaxis to infected children could reduce tuberculosis transmission.

Título traducido de la contribuciónRisk children of infection exposed and to tuberculos is disease progression at home, in Colombia
Idioma originalEspañol
Páginas (desde-hasta)261-274
Número de páginas14
PublicaciónColombia Medica
Volumen50
N.º4
DOI
EstadoPublicada - 2019

Nota bibliográfica

Publisher Copyright:
© 2019. Universidad del.

Palabras clave

  • Case finding
  • Contact Tracing
  • Contact screening
  • Latent tuberculosis
  • Mycobacterium tuberculosis
  • Pulmonary
  • Risk Factors
  • Sputum/microbiology
  • Tubercu-losis
  • Tuberculin Test
  • Tuberculosis

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