Successful kidney transplant with eculizumab, thymoglobulin and belatacept therapy in a highly sensitised patient with atypical haemolytic uraemic syndrome due to factor H mutation

John Fredy Nieto-Ríos, Mónica Zuluaga-Quintero, Diana Carolina Bello-Márquez, Arbey Aristizabal-Alzate, Catalina Ocampo-Kohn, Lina María Serna-Higuita, Lina Arias, Gustavo Zuluaga-Valencia

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2 Citas (Scopus)

Resumen

Atypical haemolytic uraemic syndrome is a disease caused by complement regulation abnormalities that generally progresses to chronic end-stage renal disease with a high rate of recurrence in kidney transplantation and a high risk of graft loss. Anti-complement therapy has improved the prognosis of these patients, achieving disease remission in most cases, increasing the likelihood of a successful kidney transplant and increasing patient and graft survival. Drugs with low risk of induction of thrombotic microangiopathies such as belatacept and mycophenolate have also been used with satisfactory results. We present the case of a young patient at high immunological risk, with atypical haemolytic uraemic syndrome due to factor H mutation, who underwent a successful kidney transplantation with eculizumab, thymoglobulin, belatacept, mycophenolate and steroids, to date preserving excellent graft function without disease recurrence.
Idioma originalEspañol (Colombia)
Páginas (desde-hasta)433-437
Número de páginas5
PublicaciónNefrologia
Volumen38
N.º4
DOI
EstadoPublicada - ene. 2018
Publicado de forma externa

Palabras clave

  • Atypical haemolytic uraemic syndrome
  • Belatacept
  • Eculizumab
  • Kidney transplantation
  • Microangiopatías trombóticas
  • Síndrome hemolítico urémico atípico
  • Thrombotic microangiopathies
  • Trasplante de riñón

Tipos de Productos Minciencias

  • Artículos de investigación con calidad Q4

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