Updated reference ranges for the ductus venosus pulsatility index at 11-13 weeks

Joan Sabria, Carmina Comas, Carles Barceló-Vidal, Raul Garcia-Posada, Monica Echevarria, Maria Dolors Gomez-Roig, Antoni Borrell

Producción científica: Contribución a una revistaArtículo en revista científica indexadarevisión exhaustiva

6 Citas (Scopus)

Resumen

Objective: To update the reference ranges for the ductus venosus pulsatility index (DVPI) at 11+0 to 13+6 gestational weeks. Methods: DVPI was calculated in 14,444 singleton fetuses at 11+0 to 13+6 weeks in two Fetal Medicine Centers, during a 4-year period. Using previously described medians, DVPI evolution was assessed both over the study period on a yearly basis and over gestation, grouping fetuses according to 5-mm crown-rump length (CRL) ranges. Weighted DVPI medians, the 5th and 95th percentiles and distribution parameters for unaffected and trisomy 21 fetuses were newly calculated. Results: A significant DVPI multiple of the median decrease was observed over both the study period (p < 0.01) and over gestation (p < 0.01) using previous medians, in the two centers. Newly calculated weighted medians were lower than those previously described, decreasing with CRL. Distribution parameters calculated using the new medians were different from those previously described. Conclusion: DVPI reference ranges were lower than those previously reported and decreased with CRL. Updated medians and distribution parameters should be considered to include the DVPI as a Gaussian marker in trisomy 21 screening and for quality control purposes.

Idioma originalInglés
Páginas (desde-hasta)271-276
Número de páginas6
PublicaciónFetal Diagnosis and Therapy
Volumen32
N.º4
DOI
EstadoPublicada - dic. 2012
Publicado de forma externa

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